dc.creator | Iglesias Linares, Alejandro | es |
dc.creator | Yañez-Vico, Rosa | es |
dc.creator | Ballesta Mudarra, Sofía | es |
dc.creator | Ortiz-Ariza, Estefanía | es |
dc.creator | Mendoza Mendoza, María Asunción | es |
dc.creator | Perea Pérez, Evelio José | es |
dc.creator | Moreno-Fernández, Ana María | es |
dc.creator | Solano Reina, José Enrique | es |
dc.date.accessioned | 2017-06-05T10:32:30Z | |
dc.date.available | 2017-06-05T10:32:30Z | |
dc.date.issued | 2013-04-30 | |
dc.identifier.citation | Iglesias Linares, A., Yañez-Vico, R., Ballesta Mudarra, S., Ortiz-Ariza, E., Mendoza Mendoza, M.A., Perea Pérez, E.J.,...,Solano Reina, J.E. (2013). Interleukin 1 receptor antagonist (IL1RN) genetic variations condition post-orthodontic external root resorption in endodontically-treated teeth. Histology and Histopathology, 28 (6), 767-773. | |
dc.identifier.issn | 02133911 | es |
dc.identifier.uri | http://hdl.handle.net/11441/60897 | |
dc.description.abstract | External pical root resorption (EARR) is a frequent iatrogenic problem following orthodontic treatment in endodontically-treated teeth, about which the literature reports substantial variability in post-orthodontic treatment EARR responses. The main focus of the present study is to clarify whether variants in the interleukin-1 receptor antagonist gene coding for the IL-1ra protein have a positive/negative influence on EARR of endodontically-treated teeth. Ninety-three orthodontic patients were genetically screened for a single nucleotide polymorphism (SNP: rs419598) in the IL1 cluster. The sample was classified into 2 groups: group 1 (affected-group) showed radiographic EARR of more than 2mm; group 2 (control-group), had no EARR or EARR <= to 2mm following orthodontic treatment on root-filled teeth. Logistic regression analysis was performed to obtain an adjusted estimate between the SNPs studied and EARR. Genotype distributions, allelic frequencies, adjusted odds ratios (OR) and 95% confidence intervals were also calculated. We found that subjects homozygous [1/1(TT)] for the IL1RN gene [OR: 10.85; p=0.001; CI: 95%] were at risk of EARR in root-filled teeth. Genetic variants in the antagonist axis balance of the IL1RN(rs419598) have a direct repercussion on the predisposition to post-orthodontic EARR in root-filled teeth. Variants in allele 1 of the interleukin-1 receptor antagonist gene(rs419598) are associated(p=0.001**) with an increased risk of suffering post-orthodontic EARR in root-filled teeth. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Universidad de Murcia. Departamento de Biología Celular e Histología | es |
dc.relation.ispartof | Histology and Histopathology, 28 (6), 767-773. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | External root resorption | es |
dc.subject | Interleukin 1 receptor antagonist | es |
dc.subject | Endodontically treated teeth | es |
dc.subject | Orthodontics | es |
dc.subject | Orthodontic treatment | es |
dc.title | Interleukin 1 receptor antagonist (IL1RN) genetic variations condition post-orthodontic external root resorption in endodontically-treated teeth | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Estomatología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica | |
idus.format.extent | 7 | es |
dc.journaltitle | Histology and Histopathology | es |
dc.publication.volumen | 28 | es |
dc.publication.issue | 6 | es |
dc.publication.initialPage | 767 | es |
dc.publication.endPage | 773 | es |