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dc.creatorIoannoni, Raphaeles
dc.creatorBeaudoin, Judees
dc.creatorLópez Maury, Luises
dc.creatorCodlin, Sandraes
dc.creatorBahler, Jurges
dc.creatorLabbe, Simones
dc.date.accessioned2017-04-28T11:00:46Z
dc.date.available2017-04-28T11:00:46Z
dc.date.issued2012
dc.identifier.citationIoannoni, R., Beaudoin, J., López Maury, L., Codlin, S., Bahler, J. y Labbe, S. (2012). Cuf2 Is a Novel Meiosis-Specific Regulatory Factor of Meiosis Maturation. PLoS One, 7 (4), e36338-1-e36338-15.
dc.identifier.issn1932-6203es
dc.identifier.urihttp://hdl.handle.net/11441/58968
dc.description.abstractBackground Meiosis is the specialized form of the cell cycle by which diploid cells produce the haploid gametes required for sexual reproduction. Initiation and progression through meiosis requires that the expression of the meiotic genes is precisely controlled so as to provide the correct gene products at the correct times. During meiosis, four temporal gene clusters are either induced or repressed by a cascade of transcription factors. Principal Findings In this report a novel copper-fist-type regulator, Cuf2, is shown to be expressed exclusively during meiosis. The expression profile of the cuf2+ mRNA revealed that it was induced during middle-phase meiosis. Both cuf2+ mRNA and protein levels are unregulated by copper addition or starvation. The transcription of cuf2+ required the presence of a functional mei4+ gene encoding a key transcription factor that activates the expression of numerous middle meiotic genes. Microscopic analyses of cells expressing a functional Cuf2-GFP protein revealed that Cuf2 co-localized with both homologous chromosomes and sister chromatids during the meiotic divisions. Cells lacking Cuf2 showed an elevated and sustained expression of several of the middle meiotic genes that persisted even during late meiosis. Moreover, cells carrying disrupted cuf2Δ/cuf2Δ alleles displayed an abnormal morphology of the forespore membranes and a dramatic reduction of spore viability. Significance Collectively, the results revealed that Cuf2 functions in the timely repression of the middle-phase genes during meiotic differentiationes
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherPublic Library of Sciencees
dc.relation.ispartofPLoS One, 7 (4), e36338-1-e36338-15.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleCuf2 Is a Novel Meiosis-Specific Regulatory Factor of Meiosis Maturationes
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Moleculares
dc.relation.publisherversionhttp://dx.doi.org/10.1371/journal.pone.0036338es
dc.identifier.doi10.1371/journal.pone.0036338es
idus.format.extent16 p.es
dc.journaltitlePLoS Onees
dc.publication.volumen7es
dc.publication.issue4es
dc.publication.initialPagee36338-1es
dc.publication.endPagee36338-15es

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