Show simple item record

dc.creatorTadeo Cervera, Irenees
dc.creatorBerbegall, Ana Pilares
dc.creatorEscudero Cuadrado, Luis Maríaes
dc.creatorÁlvaro Naranjo, Tomáses
dc.creatorNoguera Salva, Rosaes
dc.date.accessioned2017-04-07T11:43:41Z
dc.date.available2017-04-07T11:43:41Z
dc.date.issued2014
dc.identifier.issn2234-943Xes
dc.identifier.urihttp://hdl.handle.net/11441/57353
dc.description.abstractCells have the capacity to convert mechanical stimuli into chemical changes. This process is based on the tensegrity principle, a mechanism of tensional integrity. To date, this principle has been demonstrated to act in physiological processes such as mechanotransduction and mechanosensing at different scales (from cell sensing through integrins to molecular mechanical interventions or even localized massage). The process involves intra- and extracellular components, including the participation of extracellular matrix (ECM) and microtubules that act as compression structures, and actin filaments which act as tension structures. The nucleus itself has its own tensegrity system which is implicated in cell proliferation, differentiation, and apoptosis. Despite present advances, only the tip of the iceberg has so far been uncovered regarding the role of ECM compounds in influencing biotensegrity in pathological processes. Groups of cells, together with the surrounding ground substance, are subject to different and specific forces that certainly influence biological processes. In this paper, we review the current knowledge on the role of ECM elements in determining biotensegrity in malignant processes and describe their implication in therapeutic response, resistance to chemo- and radiotherapy, and subsequent tumor progression. Original data based on the study of neuroblastic tumors will be provided.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherFrontiers Mediaes
dc.relation.ispartofFrontiers in Oncology, 4, 39.es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectbiotensegrityes
dc.subjectcanceres
dc.subjectextracellular matrixes
dc.subjectmechanotherapyes
dc.subjectneuroblastomaes
dc.titleBiotensegrity of the Extracellular Matrix: Physiology, Dynamic Mechanical Balance, and Implications in Oncology and Mechanotherapyes
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessrightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Biología Celulares
dc.relation.publisherversionhttp://dx.doi.org/10.3389/fonc.2014.00039es
dc.identifier.doi10.3389/fonc.2014.00039es
dc.journaltitleFrontiers in Oncologyes
dc.publication.volumen4es
dc.publication.initialPage39es

FilesSizeFormatViewDescription
pub53fonc-04-00039.pdf3.062MbIcon   [PDF] View/Open  

This item appears in the following collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional