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dc.creatorCorrales Guerrero, Lauraes
dc.creatorFlores García, Enriquees
dc.creatorHerrero Moreno, Antoniaes
dc.date.accessioned2017-04-07T07:42:52Z
dc.date.available2017-04-07T07:42:52Z
dc.date.issued2014
dc.identifier.citationCorrales Guerrero, L., Flores Garcia, E. y Herrero Moreno, A. (2014). Relationships between the ABC-exporter HetC and peptides that regulate the spatiotemporal pattern of heterocyst distribution in Anabaena. Plos One, 9 (8), e104571-1-e104571-17.
dc.identifier.issn1932-6203es
dc.identifier.urihttp://hdl.handle.net/11441/57327
dc.description.abstractIn the model cyanobacterium Anabaena sp. PCC 7120, cells called heterocysts that are specialized in the fixation of atmospheric nitrogen differentiate from vegetative cells of the filament in the absence of combined nitrogen. Heterocysts follow a specific distribution pattern along the filament, and a number of regulators have been identified that influence the heterocyst pattern. PatS and HetN, expressed in the differentiating cells, inhibit the differentiation of neighboring cells. At least PatS appears to be processed and transferred from cell to cell. HetC is similar to ABC exporters and is required for differentiation. We present an epistasis analysis of these regulatory genes and of genes, hetP and asr2819, successively downstream from hetC, and we have studied the localization of HetC and HetP by use of GFP fusions. Inactivation of patS, but not of hetN, allowed differentiation to proceed in a hetC background, whereas inactivation of hetC in patS or patS hetN backgrounds decreased the frequency of contiguous proheterocysts. A HetC-GFP protein is localized to the heterocysts and especially near their cell poles, and a putative HetC peptidase domain was required for heterocyst differentiation but not for HetC-GFP localization. hetP is also required for heterocyst differentiation. A HetP-GFP protein localized mostly near the heterocyst poles. ORF asr2819, which we denote patC, encodes an 84-residue peptide and is induced upon nitrogen step-down. Inactivation of patC led to a late spreading of the heterocyst pattern. Whereas HetC and HetP appear to have linked functions that allow heterocyst differentiation to progress, PatC may have a role in selecting sites of differentiation, suggesting that these closely positioned genes may be functionally relatedes
dc.description.sponsorshipGobierno de España BFU2010-17980es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherPublic Library of Sciencees
dc.relation.ispartofPlos One, 9 (8), e104571-1-e104571-17.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAnabaenaes
dc.subjectATP-Binding Cassette Transporterses
dc.subjectBacterial Proteinses
dc.titleRelationships between the ABC-exporter HetC and peptides that regulate the spatiotemporal pattern of heterocyst distribution in Anabaenaes
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Moleculares
dc.relation.projectIDBFU2010-17980es
dc.relation.publisherversionhttp://dx.doi.org/10.1371/journal.pone.0104571es
dc.identifier.doi10.1371/journal.pone.0104571es
idus.format.extent17 p.es
dc.journaltitlePlos Onees
dc.publication.volumen9es
dc.publication.issue8es
dc.publication.initialPagee104571-1es
dc.publication.endPagee104571-17es
dc.contributor.funderGobierno de España

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