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Artículo
Intermolecular displacement of S-bound L-methionine on platinum(II) by guanosine 5′-monophosphate: Implications for the mechanism of action of anticancer drugs
dc.creator | Barnham, Kevin J. | es |
dc.creator | Djuran, Milos I. | es |
dc.creator | Murdoch, Piedad del Socorro | es |
dc.creator | Sadler, Peter J. | es |
dc.date.accessioned | 2016-05-05T07:56:59Z | |
dc.date.available | 2016-05-05T07:56:59Z | |
dc.date.issued | 1994 | |
dc.identifier.issn | 0022-4936 | es |
dc.identifier.uri | http://hdl.handle.net/11441/40764 | |
dc.description.abstract | NMR investigations of the kinetics and thermodynamics of the competitive binding of L-methionine (Met), L-histidine (His), and 5′-monophosphates of guanosine (5′-GMP), adenosine (5′-AMP), thymidine (5′-TMP) and cytidine (5′-CMP) to [Pt(dien)Cl]+ (dien = 1,5-diamino-3-azapentane) in aqueous solution show that 5′-GMP selectively displaces S-bound Met, a finding which has implications for DNA platination by anticancer drugs in vivo. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Chemical Society | es |
dc.relation.ispartof | Journal of the Chemical Society - Series Chemical Communications, 6, 721-722 | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Adenosine phosphate | es |
dc.subject | Antineoplastic agent | es |
dc.subject | Cytidine phosphate | es |
dc.subject | Guanosine phosphate | es |
dc.subject | Histidine | es |
dc.subject | Methionine | es |
dc.subject | Platinum derivative | es |
dc.subject | Thymidine phosphate | es |
dc.title | Intermolecular displacement of S-bound L-methionine on platinum(II) by guanosine 5′-monophosphate: Implications for the mechanism of action of anticancer drugs | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular | es |
dc.relation.publisherversion | 10.1039/C39940000721 | es |
dc.identifier.doi | http://dx.doi.org/10.1039/C39940000721 | es |
idus.format.extent | 2 p. | es |
dc.identifier.idus | https://idus.us.es/xmlui/handle/11441/40764 |
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