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Artículo
Hydroxytyrosol and Dopamine Metabolites: Anti-aggregative Effect and Neuroprotective Activity Against α-synuclein-induced Toxicity
(Elsevier, 2023)
The abnormal aggregation of the α-synuclein (αsyn) protein is involved in the formation of Lewy bodies in the brain of patients suffering from Parkinson disease (PD). Hydroxytyrosol (HT), a polyphenolic compound present ...
Artículo
Melatonin, Protocatechuic Acid and Hydroxytyrosol Effects on Vitagenes System Against Alpha-Synuclein Toxicity
(Elsevier, 2019)
Preventing the abnormal assembly of α-synuclein (α-Syn) and the correct modulation of vitagenes system exercise strong neuroprotective effects. It has been reported that melatonin (MEL), protocatechuic acid (PCA) and ...
Artículo
Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In Vitro
(MDPI, 2020)
Neuroinflammation is a common feature shared by neurodegenerative disorders, such as Parkinson’sdisease(PD),andseemstoplayakeyroleintheirdevelopmentandprogression. Microglia cells, the principal orchestrators of neuroinflammation, ...