Artículo
Metallomic and Untargeted Metabolomic Signatures of Human Milk from SARS-CoV-2 Positive Mothers
Autor/es | Arias Borrego, Ana
Soto Cruz, Francisco J. Selma Royo, Marta Bäuerl, Christine García Verdevio, Elia Pérez Cano, Francisco J. Lerin, Carles Velasco López, Inés Martínez Costa, Cecilia Collado, M. Carmen García Barrera, Tamara |
Departamento | Universidad de Sevilla. Departamento de Química Analítica |
Fecha de publicación | 2022 |
Fecha de depósito | 2024-08-16 |
Publicado en |
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Resumen | Scope
Lack of information about the impact of maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the elemental and metabolomic profile of human milk (HM).
Methods and results
An ... Scope Lack of information about the impact of maternal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on the elemental and metabolomic profile of human milk (HM). Methods and results An observational study on HM from mothers with COVID-19 is conducted including a prepandemic control group. Maternal–infant clinical records and symptomatology are recorded. The absolute quantification of elements and untargeted relative metabolomic profiles are determined by inductively coupled plasma mass spectrometry and gas chromatography coupled to mass spectrometry, respectively. Associations of HM SARS-CoV-2 antibodies with elemental and metabolomic profiles are studied. COVID-19 has a significant impact on HM composition. COVID-19 reduces the concentrations of Fe, Cu, Se, Ni, V, and Aluminium (Al) and increases Zn compared to prepandemic control samples. A total of 18 individual metabolites including amino acids, peptides, fatty acids and conjugates, purines and derivatives, alcohols, and polyols are significantly different in HM from SARS-CoV-2 positive mothers. Aminoacyl-tRNA biosynthesis, phenylalanine, tyrosine and tryptophan biosynthesis, phenylalanine, and linoleic acid pathways are significantly altered. Differences are obtained depending on COVID-19 symptomatic and asymptomatic status. Conclusions This study provides unique insights about the impact of maternal SARS-CoV-2 infection on the elemental and metabolomic profiles of HM that warrants further research due the potential implications for infant health. |
Agencias financiadoras | Ministerio de Ciencia e Innovación (MICIN). España Junta de Andalucía Fundación La Marató-TV3 Universidad de Huelva European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) |
Identificador del proyecto | PG2018-096608-B-C21
UHU-1256905 UHU-202009 02106 SNGJ5-TS-005 UNHU13-1E-1611 UNHU15-CE-3140 |
Cita | Arias Borrego, A., Soto Cruz, F.J., Selma Royo, M., Bäuerl, C., García Verdevio, E., Pérez Cano, F.J.,...,García Barrera, T. (2022). Metallomic and Untargeted Metabolomic Signatures of Human Milk from SARS-CoV-2 Positive Mothers. Molecular Nutrition & Food Research, 66 (16), 2200071. https://doi.org/10.1002/mnfr.202200071. |
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