dc.creator | López Bueno, Rubén | es |
dc.creator | Calatayud, Joaquín | es |
dc.creator | Pozo Cruz, Jesús del | es |
dc.creator | Yang, Lin | es |
dc.creator | Pozo Cruz, Borja del | es |
dc.date.accessioned | 2024-07-10T10:37:56Z | |
dc.date.available | 2024-07-10T10:37:56Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | López Bueno, R., Calatayud, J., Pozo Cruz, J.d., Yang, . y Pozo Cruz, B.d. (2024). Dose-response associations of the American Heart Association's new “Life's essential 8” metrics with all-cause and cardiovascular mortality in a nationally representative sample from the United States. Progress in Cardiovascular Diseases, 1-31. https://doi.org/10.1016/j.pcad.2024.06.001. | |
dc.identifier.issn | 0033-0620 | es |
dc.identifier.issn | 1873-1740 | es |
dc.identifier.uri | https://hdl.handle.net/11441/161257 | |
dc.description.abstract | Background
Our aim was to examine the prospective dose-response associations of American Heart
Association´s (AHA) LIFE´s Essential 8 (LE8) score and number of cardiovascular health
(CVH) factors with high score with all-cause and cardiovascular disease (CVD) related
mortality.
Methods
We pooled 6 consecutive waves of the National Health and Nutrition Examination Survey
(NHANES) comprising rounds between 2007-2008 and 2017-2018. We calculated hazard
ratios (HRs) and conducted restricted cubic splines models to assess the dose-response
association of LE8 score and CVH factors with all-cause and CVD mortality.
Results
Analyses included 23 531 adults aged 18 years and over (mean [SD] age, 43.6 [16.7] years;
11 979 [51%] female; 8960 [38.1%] non-Hispanic white individuals) with a median follow-up
of 7.3 years (IQR 4.3-10.1), corresponding to 168 033 person-years.
The dose-response analyses showed a significant inverse curvilinear trend for the association
between LE8 score with all-cause and CVD mortality. The optimal risk reduction for all
cause mortality was found at 100 points of the LE8 Score (HR, 0.50; 95% CI, 0.27-0.93)
compared to the reference (median LE8 score [62.5 points]). Moreover, the dose-response
association between LE8 and CVD mortality also exhibited a significant inverse curvilinear
association up to 90 points (HR, 0.41; 95% CI, 0.17-0.99). Optimal levels of LE8 score may
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be able to avert around 40% of the annual all-cause and CVD deaths among the US adult
population.
Conclusions
Best-case scenario of CVH may reduce around 40% of the all-cause and CVD annual
mortality among adults in the United States. | es |
dc.format | application/pdf | es |
dc.format.extent | 31 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Progress in Cardiovascular Diseases, 1-31. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Preventive medicine | es |
dc.subject | Epidemiology | es |
dc.subject | Public health | es |
dc.subject | Risk factors | es |
dc.subject | Lifestyle | es |
dc.title | Dose-response associations of the American Heart Association's new “Life's essential 8” metrics with all-cause and cardiovascular mortality in a nationally representative sample from the United States | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Educación Física y Deporte | es |
dc.relation.publisherversion | https://doi.org/10.1016/j.pcad.2024.06.001 | es |
dc.identifier.doi | 10.1016/j.pcad.2024.06.001 | es |
dc.contributor.group | Universidad de Sevilla. HUM1055: Epidemiology of Physical Activity and Fitness Across Lifespan | es |
idus.validador.nota | Paqui | es |
dc.journaltitle | Progress in Cardiovascular Diseases | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 31 | es |