Article
Influence of sodium hyaluronate concentration in tear meniscus height: 10 minutes dynamic profile after single instillation
Author/s | Rocha de Lossada, Carlos
![]() ![]() ![]() ![]() ![]() Sánchez González, José María ![]() ![]() ![]() ![]() ![]() ![]() ![]() Zamorano Martín, Francisco Rachwani-Anil, Rahul Torras-Sanvicens, Josep Peraza-Nieves, Jorge |
Department | Universidad de Sevilla. Departamento de Física de la Materia Condensada |
Publication Date | 2021 |
Deposit Date | 2024-06-11 |
Published in |
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Abstract | Purpose: To assess the height, area, and density of tear meniscus throughout 10 min after instillation of sodium hyaluronate (SH) of equal molecular weight at two different concentrations. Methods: Thirty-four eyes from ... Purpose: To assess the height, area, and density of tear meniscus throughout 10 min after instillation of sodium hyaluronate (SH) of equal molecular weight at two different concentrations. Methods: Thirty-four eyes from 17 patients were enrolled in this longitudinal, nonrandomized, interventional and contralateral eye study. Tear meniscus height (TMH), corneal meniscus junction (CMJ), lower-lid meniscus junction (LLMJ), and tear meniscus area (TMA) images were obtained with the anterior segment module of the deep range imaging ocular coherence tomography ([DRI-OCT] Triton Swept-Source). Tear meniscus density (TMD) was calculated using the image processing and analysis software by Java (ImageJ program). Sodium hyaluronate artificial tears at 0.1% and 0.2% concentrations were instilled into all right and left eyes, respectively. Results: Patients' mean age was 61.05±11.43 years. Tear meniscus height, CMJ, LLMJ, and TMA measured at 1-, 5-, 7- and 10-min postinstillation of 0.1% SH proved significant differences among them (P<0.05). Sodium hyaluronate 0.2% instillation obtained similar findings, although no significant differences were found between 1- and 3-min postinstillation measurements (P>0.05). Fewer differences were found in TMD 0.2% SH group due to a lower baseline densitometry compared to the 0.1% group. Conclusion: 0.2% sodium hyaluronate achieved better TMH and TMA in 1 and 3 min after instillation than 0.1% concentration. However, there were no statistically significant differences between 0.1% and 0.2% sodium hyaluronate throughout a ten-minute longitudinal profile measurement using DRI-OCT. |
Citation | Rocha de Lossada, C., Sánchez González, J.M., Zamorano Martín, F., Rachwani-Anil, R., Torras-Sanvicens, J. y Peraza-Nieves, J. (2021). Influence of sodium hyaluronate concentration in tear meniscus height: 10 minutes dynamic profile after single instillation. Eye & Contact Lens-Science and Clinical Practice, 47 (6), 330-334. https://doi.org/10.1097/ICL.0000000000000733. |
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