Artículo
Impact of Dyslipidemia on Tear Film and Meibomian Gland Dysfunction: A Cross-Sectional Study of the Interplay between Serum Lipid Profile and Ocular Surface Health
Autor/es | Serrano Morales, José Manuel
Álvarez Santaliestra, Noelia Sánchez González, María del Carmen Ballesteros Sánchez, Antonio Sánchez González, José María |
Departamento | Universidad de Sevilla. Departamento de Física de la Materia Condensada |
Fecha de publicación | 2024 |
Fecha de depósito | 2024-06-04 |
Publicado en |
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Resumen | Purpose. To determine the relationship between dyslipidemia and dry eye disease (DED), as well as its influence on tear 6lm and meibomian glands. Methods. ,is cross-sectional study included 40 patients with a mean age of ... Purpose. To determine the relationship between dyslipidemia and dry eye disease (DED), as well as its influence on tear 6lm and meibomian glands. Methods. ,is cross-sectional study included 40 patients with a mean age of 35.2 ± 13.9 years without any history of dyslipidemia. DED and serum lipid profile were evaluated after 8 hours of fasting. Patients were classified according to serum lipid levels with the following cut-off values: total cholesterol (TC) (200 mg/dl), high-density lipoprotein (HDL) (40 mg/dl), low-density lipoprotein (LDL) (130 mg/dl), and triglycerides (TG) (150 mg/dl). The relationship between serum lipid levels and DED was analyzed with the following variables: dry eye questionnaire-5 (DEQ-5), 6rst (F-NIBUT) and average (A-NIBUT) noninvasive breakup time, tear meniscus height (TMH), lipid layer grade (LLG), conjunctival bulbar redness (CBR), and upper (U-LAMG) and lower (L-LAMG) loss area of meibomian glands. Results. Regarding tear 6lm, patients with elevated TC and LDL levels reported significantly higher DEQ-5 scores and TMH (P < 0.05), while those with lower HDL levels showed significantly higher LLG (p < 0.05). Regarding MGD, patients with elevated TC, LDL, and TG, as well as lower HDL levels showed significantly higher L-LAMG (p < 0.05). HDL was correlated with LLG (p < 0.05), while TC was correlated with TMH (p < 0.05) and L-LAMG (p < 0.05), respectively. Conclusions. Disorders in TC, HDL, LDL, and TG levels were associated with DED, having an impact on the tear film and meibomian glands, specifically in DEQ-5 scores, LLG, and L-LAMG. |
Cita | Serrano Morales, J.M., Álvarez Santaliestra, N., Sánchez González, M.d.C., Ballesteros Sánchez, A. y Sánchez González, J.M. (2024). Impact of Dyslipidemia on Tear Film and Meibomian Gland Dysfunction: A Cross-Sectional Study of the Interplay between Serum Lipid Profile and Ocular Surface Health. Journal of Ophthalmology, 2024, 7345270. https://doi.org/10.1155/2024/7345270. |
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