Artículo
Chitosan-based hydrogels obtained via photoinitiated click polymer IPN reaction
Autor/es | Sánchez Cid, Pablo
Romero García, Alberto ![]() ![]() ![]() ![]() ![]() ![]() ![]() Paz Báñez, María Violante de ![]() ![]() ![]() ![]() ![]() ![]() ![]() Pérez-Puyana, Víctor Manuel |
Departamento | Universidad de Sevilla. Departamento de Ingeniería Química Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica Universidad de Sevilla. Departamento de Ingeniería Química y Ambiental |
Fecha de publicación | 2023-06 |
Fecha de depósito | 2024-05-29 |
Resumen | Chitosan (CTS) is a polysaccharide with a wide variety of applications in the biomedical field, owing to its outstanding disinfectant properties, biocompatibility and biodegradability, but with limited mechanical properties. ... Chitosan (CTS) is a polysaccharide with a wide variety of applications in the biomedical field, owing to its outstanding disinfectant properties, biocompatibility and biodegradability, but with limited mechanical properties. The proposed strategy to improve CTS-based hydrogel properties in this study is the formation of a semi-interpenetrating polymer network (semi-IPN). In this way, a photo-initiated radical click reaction was proposed to obtain a synthetic polymer, whose components were included in a CTS solution, resulting in the semi-IPN network after UV illumination. Different crosslinking degrees (CD) and CTS/polymer ratios were evaluated through rheological characterization, along with an assessment of both variables based on an experimental model design, obtaining that, for every CTS/polymer ratio, intermediate values of CD (8 %) offered the best rheological properties. In addition, chemical and microstructural characterization were carried out for selected hydrogels, obtaining consistent results according to rheological characterization, as the 1/1 CTS/polymer ratio with CD 8 % hydrogel displayed the most homogeneous pore size and distribution, consequently leading to the best rheological performance. |
Agencias financiadoras | Ministerio de Ciencia e Innovación (MICIN). España European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) European Commission. Fondo Social Europeo (FSO) |
Identificador del proyecto | PID2021-124294OB-C21
![]() PAIDI DOCTOR 2019–2020 DOC_00586 ![]() |
Ficheros | Tamaño | Formato | Ver | Descripción |
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JML_romero-garcia_2023_chitosan.pdf | 2.523Mb | ![]() | Ver/ | |
JML_romero-garcia_2023_corrgen ... | 242.7Kb | ![]() | Ver/ | |