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Artículo
Microbubble generation in a co-flow device operated in a new regime
Autor/es | Castro Hernández, Elena De
Hoeve, Wim Van Lohse, Detlef Gordillo Arias de Saavedra, José Manuel |
Departamento | Universidad de Sevilla. Departamento de Ingeniería Aeroespacial y Mecánica de Fluidos |
Fecha de publicación | 2011-06 |
Fecha de depósito | 2024-05-24 |
Publicado en |
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Resumen | A new regime of operation of PDMS-based flow-focusing microfluidic devices is presented. We show that monodisperse microbubbles with diameters below one-tenth of the channel width (here w = 50µm) can be produced in low ... A new regime of operation of PDMS-based flow-focusing microfluidic devices is presented. We show that monodisperse microbubbles with diameters below one-tenth of the channel width (here w = 50µm) can be produced in low viscosity liquids thanks to a strong pressure gradient in the entrance region of the channel. In this new regime bubbles are generated at the tip of a long and stable gas ligament whose diameter, which can be varied by tuning appropriately the gas and liquid flow rates, is substantially smaller than the channel width. Through this procedure the volume of the bubbles formed at the tip of the gas ligament can be varied by more than two orders of magnitude. The experimental results for the bubble diameter db as function of the control parameters are accounted for by a scaling theory, which predicts db/w ∝ (µg/µℓ)1/12 (Qg/Qℓ )5/12 , where µg and µℓ indicate, respectively, the gas and liquid viscosities and Qg and Qℓ are the gas and liquid flow rates. As a particularly important application of our results we produce monodisperse bubbles with the appropriate diameter for therapeutical applications (db ≃5µm) and a production rate exceeding 105 Hz. |
Agencias financiadoras | Ministerio de Educación. España Junta de Andalucía |
Identificador del proyecto | DPI2008-06624-C03-01
P08-TEP-03997 |
Cita | Castro Hernández, E.D., Hoeve, W.V., Lohse, D. y Gordillo Arias de Saavedra, J.M. (2011). Microbubble generation in a co-flow device operated in a new regime. Lab on a Chip, 11 (12), 2023-2029. https://doi.org/10.1039/c0lc00731e. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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LabChip2011_.pdf | 2.219Mb | [PDF] | Ver/ | Versión aceptada |