dc.creator | Laseca, Nora | es |
dc.creator | Perdomo-González, Davinia I. | es |
dc.creator | Valera Córdoba, María Mercedes | es |
dc.creator | Demyda-Peyrás, Sebastián | es |
dc.creator | Ziadi, Chiraz | es |
dc.creator | Molina, Antonio | es |
dc.date.accessioned | 2024-05-09T14:32:13Z | |
dc.date.available | 2024-05-09T14:32:13Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Laseca, N., Perdomo-González, D.I., Valera Córdoba, M.M., Demyda-Peyrás, S., Ziadi, C. y Molina, A. (2024). Reproductive traits in Pura Raza Española mares manifest inbreeding depression from low levels of homozygosity. Journal of animal breeding and genetics, 1-12. https://doi.org/10.1111/jbg.12856. | |
dc.identifier.issn | Online:1439-0388 | es |
dc.identifier.issn | 0931-2668 | es |
dc.identifier.uri | https://hdl.handle.net/11441/158015 | |
dc.description.abstract | Inbreeding depression is a genetic phenomenon associated with the loss of fitness
and mean phenotypic performance due to mating between relatives. Historically,
inbreeding coefficients have been estimated from pedigree information. However,
the onset of genomic selection programs provides large datasets of individuals
genotyped using SNP arrays, enabling more precise assessment of an individual's
genomic-level
inbreeding using genomic data. One of the traits most sensitive to
issues stemming from increased inbreeding is reproduction. This is particularly
important in equine, in which fertility is only moderate compared to other livestock
species. To explore this further, we evaluated the effect of inbreeding on five
reproductive traits (age at first foaling (AFF), average interval between foalings
(AIF), total number of foalings (NF), productive life (PL) and reproductive efficiency
(RE)) in Pura Raza Español mares using genomic data. Residual predicted
phenotypes were obtained by purging these traits through the REML (wgResidual)
and ssGREML (gResidual) approaches in reproductive data of 29,847 PRE mares
using the BLUPF90+ program. Next, we used pedigree-based
(Fped) and ROH-based
genomic (FROH) inbreeding coefficients derived from 1018 animals genotyped
with 61,271 SNPs to estimate the inbreeding depression (linear regression).
Our results indicated significant levels of inbreeding depression for all reproductive
traits, with the exception of the AIF trait when Fped was used. However, all
traits were negatively affected by the increase in genomic inbreeding, and FROH
was found to capture more inbreeding depression than Fped. Likewise, REML
models (ssGREML) using genomic data for estimated predicted residual phenotypes
resulted in higher variance explained by the model compared with the
models not using genomics (REML). Finally, a segmented regression analysis was
conducted to evaluate the effect of inbreeding depression, revealing that the levels
of genealogical and genomic homozygosity do not manifest uniformly in reproductive
traits. In contrast, the levels of inbreeding depression ranged from low
to high as homozygosity increased. This analysis also showed that reproductive traits are very sensitive to inbreeding depression, even with relatively low levels
of homozygosity. | es |
dc.format | application/pdf | es |
dc.format.extent | 12 | es |
dc.language.iso | eng | es |
dc.publisher | Wiley | es |
dc.relation.ispartof | Journal of animal breeding and genetics, 1-12. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | fertility | es |
dc.subject | genomic inbreeding | es |
dc.subject | horse | es |
dc.subject | runs of homozygosity | es |
dc.subject | segmented regression | es |
dc.title | Reproductive traits in Pura Raza Española mares manifest inbreeding depression from low levels of homozygosity | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Agronomía | es |
dc.relation.publisherversion | https://doi.org/10.1111/jbg.12856 | es |
dc.identifier.doi | 10.1111/jbg.12856 | es |
dc.contributor.group | Universidad de Sevilla.AGR273: Nuevas tecnologías de mejora animal y de sus sistemas reproductivos. | es |
dc.journaltitle | Journal of animal breeding and genetics | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 12 | es |