dc.creator | Gómez Oliva, Ricardo | es |
dc.creator | Martínez Ortega, Sergio | es |
dc.creator | Atienza Navarro, Isabel | es |
dc.creator | Domínguez García, Samuel | es |
dc.creator | Bernal Utrera, Carlos | es |
dc.creator | Geribaldi Doldan, Noelia | es |
dc.creator | Verastegui, Cristina | es |
dc.creator | Núñez Abades, Pedro Antonio | es |
dc.creator | García Alloza, Mónica | es |
dc.creator | Castro, Carmen | es |
dc.date.accessioned | 2024-05-08T10:26:09Z | |
dc.date.available | 2024-05-08T10:26:09Z | |
dc.date.issued | 2023-03-19 | |
dc.identifier.citation | Gómez Oliva, R., Martínez Ortega, S., Atienza Navarro, I., Domínguez García, S., Bernal Utrera, C., Geribaldi Doldan, N.,...,Castro, C. (2023). Rescue of neurogenesis and age-associated cognitive decline in SAMP8 mouse: Role of transforming growth factor-alpha. Aging Cell, 22 (6), e13829. https://doi.org/10.1111/acel.13829. | |
dc.identifier.issn | 1474-9718 | es |
dc.identifier.issn | 1474-9726 | es |
dc.identifier.uri | https://hdl.handle.net/11441/157876 | |
dc.description.abstract | Neuropathological aging is associated with memory impairment and cognitive decline, affecting several brain areas including the neurogenic niche of the dentate gyrus of the hippocampus (DG). In the healthy brain, homeostatic mechanisms regulate neuro -genesis within the DG to facilitate the continuous generation of neurons from neural stem cells (NSC). Nevertheless, aging reduces the number of activated neural stem cells and diminishes the number of newly generated neurons. Strategies that promote neurogenesis in the DG may improve cognitive performance in the elderly resulting in the development of treatments to prevent the progression of neurological disorders in the aged population. Our work is aimed at discovering targeting molecules to be used in the design of pharmacological agents that prevent the neurological effects of brain aging. We study the effect of age on hippocampal neurogenesis using the SAMP8 mouse as a model of neuropathological aging. We show that in 6- month-old SAMP8 mice, episodic and spatial memory are impaired; concomitantly, the genera -tion of neuroblasts and neurons is reduced and the generation of astrocytes is in-creased in this model. The novelty of our work resides in the fact that treatment of SAMP8 mice with a transforming growth factor- alpha (TGFα) targeting moleculeprevents the observed defects, positively regulating neurogenesis and improving cog-nitive performance. This compound facilitates the release of TGFα in vitro and in vivo and activates signaling pathways initiated by this growth factor. We conclude that compounds of this kind that stimulate neurogenesis may be useful to counteract the neurological effects of pathological agin | es |
dc.description.sponsorship | Agencia Estatal de Investigacion RTI-2018-099908-B-C21; RTI-2018-099908-B-C22 | es |
dc.description.sponsorship | Consejeria de Economia, Innovacion, Ciencia y Empleo, Junta de Andalucia, Fondos FEDER FEDER-UCA18-106647 | es |
dc.description.sponsorship | Consejeria de Salud, Junta de Andalucia, FEDER fondos regionales integrados (ITI) ITI-Cadiz-0042-2019 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Wiley Open Access | es |
dc.relation.ispartof | Aging Cell, 22 (6), e13829. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | adult hippocampal neurogenesis | es |
dc.subject | agin | es |
dc.subject | dentate gyru | es |
dc.subject | diterpene | es |
dc.subject | memory | es |
dc.subject | neuroregeneratio | es |
dc.subject | , transforming growth factor-alpha | es |
dc.title | Rescue of neurogenesis and age-associated cognitive decline in SAMP8 mouse: Role of transforming growth factor-alpha | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología | es |
dc.relation.projectID | RTI-2018-099908-B-C21 | es |
dc.relation.projectID | RTI-2018-099908-B-C22 | es |
dc.relation.projectID | FEDER-UCA18-106647 | es |
dc.relation.projectID | ITI-Cadiz-0042-2019 | es |
dc.relation.publisherversion | https://doi.org/10.1111/acel.13829 | es |
dc.identifier.doi | 10.1111/acel.13829 | es |
dc.journaltitle | Aging Cell | es |
dc.publication.volumen | 22 | es |
dc.publication.issue | 6 | es |
dc.publication.initialPage | e13829 | es |
dc.contributor.funder | Agencia Estatal de Investigación. España | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |
dc.contributor.funder | Junta de Andalucía | es |