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Bioconcentration of pharmaceuticals in benthic marine organisms (Holothuria tubulosa, Anemonia sulcata and Actinia equina) exposed to environmental contamination by atenolol and carbamazepine
dc.creator | Gómez-Regalado, María del Carmen | es |
dc.creator | Martín Bueno, Julia | es |
dc.creator | Hidalgo, Félix | es |
dc.creator | Santos Morcillo, Juan Luis | es |
dc.creator | Aparicio Gómez, Irene | es |
dc.creator | Alonso Álvarez, Esteban | es |
dc.creator | Zafra-Gómez, Alberto | es |
dc.date.accessioned | 2024-04-30T09:25:23Z | |
dc.date.available | 2024-04-30T09:25:23Z | |
dc.date.issued | 2023-06 | |
dc.identifier.issn | 1382-6689 | es |
dc.identifier.issn | 1872-7077 | es |
dc.identifier.uri | https://hdl.handle.net/11441/157319 | |
dc.description.abstract | The present work assess the bioconcentration kinetics of atenolol (ATN) and carbamazepine (CBZ) in common marine organisms including Holothuria tubulosa, Anemonia sulcata and Actinia equina under controlled laboratory conditions. CBZ exhibited higher uptake and excretion rates resulting higher bioconcentration factor (BCF) (41–537 L/kg for CBZ vs 7–50 L/kg for ATN) although both are below the limits established by the European Union (EU). The measured BCF using kinetic data showed some differences with those predicted using the concentrations measured at the steady-state, probably explained because the steady state was not ready reached. The animal-specific BCF followed the order of Holothuria tubulosa > Actinia equina > Anemonia sulcata for ATN while was the opposite for CBZ. The study highlighted between-tissues differences in the digestive tract and the body wall of the Holothuria tubulosa. The work presented is the first to model bioconcentration of ATN and CBZ in holothurian and anemone animal models. | es |
dc.format | application/pdf | es |
dc.format.extent | 30 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Atenolol | es |
dc.subject | Carbamazepine | es |
dc.subject | Up-take/Depuration | es |
dc.subject | Animal model | es |
dc.subject | Benthic organisms | es |
dc.title | Bioconcentration of pharmaceuticals in benthic marine organisms (Holothuria tubulosa, Anemonia sulcata and Actinia equina) exposed to environmental contamination by atenolol and carbamazepine | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/embargoedAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química Analítica | es |
dc.relation.projectID | PID2020-117641RB-I00 | es |
dc.relation.projectID | B.RNM.362. UGR20 | es |
dc.relation.projectID | P20_00556 | es |
dc.date.embargoEndDate | 2024-07-01 | |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S1382668923000893 | es |
dc.identifier.doi | 10.1016/j.etap.2023.104147 | es |
dc.contributor.group | Universidad de Sevilla. FQM344: Análisis Químico Industrial y Medioambiental | es |
dc.journaltitle | Environmental Toxicology and Pharmacology | es |
dc.publication.volumen | 100 | es |
dc.publication.issue | 104147 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | Junta de Andalucía | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |
Ficheros | Tamaño | Formato | Ver | Descripción |
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ETP_martin-bueno_2023_bioconce ... | 1.611Mb | ![]() | Ver/ | Postprint. Accepted Version |