Artículo
Uptake and depuration of three common antibiotics in benthic organisms: sea cucumber (Holothuria tubulosa), snakelocks anemone (Anemonia sulcata) and beadlet anemone (Actinia equina)
Autor/es | Gómez-Regalado, María del Carmen
Martín Bueno, Julia Hidalgo, Félix Santos Morcillo, Juan Luis Aparicio Gómez, Irene Alonso Álvarez, Esteban Zafra-Gómez, Alberto |
Departamento | Universidad de Sevilla. Departamento de Física Aplicada I |
Fecha de publicación | 2023-09 |
Fecha de depósito | 2024-04-30 |
Resumen | Antibiotics are widely used drugs in human and veterinary medicine, which has attracted great attention in relation to the development of bacterial resistance, currently a problem of great concern for governments and states, ... Antibiotics are widely used drugs in human and veterinary medicine, which has attracted great attention in relation to the development of bacterial resistance, currently a problem of great concern for governments and states, as it is related to the resurgence of infectious diseases already eradicated. Understanding the bioaccumulation of antibiotics in aquatic organisms is an important key to understanding their risk assessment. The present study was designed to study the bioaccumulation of target antibiotics in relevant organisms inhabiting benthic marine environments. The uptake and elimination of ciprofloxacin (CIP), sulfamethoxazole (SMX) and trimethoprim (TMP) were investigated in sea cucumbers (Holothuria tubulosa), snakelock anemone (Anemonia sulcata) and beadlet anemone (Actinia equina) under controlled laboratory conditions. The results show that antibiotics have a particular trend over time during all periods of absorption and depuration. The tissue distribution of antibiotics in sea cucumber is strongly influenced by the structure of the compounds, while CIP is concentrated in the body wall; TMP is concentrated in the digestive tract. Two different approaches were used to estimate bioconcentration factors (BCFs) in different animal models, based on toxicokinetic data and measured steady-state concentrations. The BCF ranges were 456–2731 L/kg, 6–511 L/kg and 9–100 L/kg for TMP, CIP and SMX, respectively. The estimated BCF values obtained classify TMP as cumulative in A. equina and H. tubulosa, underlining the potential bioconcentration in these marine organisms. A correlation was observed between the BCFs of the target antibiotics and the octanol-water distribution coefficient (Dow) (r² > 0.7). The animal-specific BCF followed the order of beadlet anemone > sea cucumber > snakelock anemone. |
Agencias financiadoras | Ministerio de Ciencia e Innovación (MICIN). España Junta de Andalucía European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) |
Identificador del proyecto | PID2020-117641RB-I00
B.RNM.362.UGR20 P20_00556 |
Ficheros | Tamaño | Formato | Ver | Descripción |
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ER_martin-bueno_2023_uptake.pdf | 3.142Mb | [PDF] | Este documento no está disponible a texto completo hasta el 2024-10-01 . Para más información póngase en contacto con idus@us.es. | Postprint. Accepted Version |