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dc.creatorCalderón-Parra, Jorgees
dc.creatorDomínguez, Fernandoes
dc.creatorGonzález-Rico, Claudiaes
dc.creatorArnaiz de las Revillas, Franciscoes
dc.creatorGoenaga, Miguel Ángeles
dc.creatorÁlvarez, I.es
dc.creatorMuñoz, Patriciaes
dc.creatorAlonso, Davides
dc.creatorRodríguez-García, Raqueles
dc.creatorMiró, José Maríaes
dc.creatorSpanish Collaboration on Endocarditis (GAMES)es
dc.creatorAraji Tiliani, Omares
dc.creatorCueto López, Marina dees
dc.creatorGutiérrez Carretero, Encarnaciónes
dc.creatorLepe Jiménez, José Antonioes
dc.creatorLópez-Cortes, Luis Eduardoes
dc.date.accessioned2024-04-23T14:10:10Z
dc.date.available2024-04-23T14:10:10Z
dc.date.issued2024
dc.identifier.citationCalderón-Parra, J., Domínguez, F., González-Rico, C., Arnaiz de las Revillas, F., Goenaga, M.Á., Álvarez, I.,...,López-Cortes, L.E. (2024). Epidemiology and risk factors of mycotic aneurysm in patients with infective endocarditis and the impact of its rupture in outcomes. Analysis of a national prospective cohort. Open Forum Infectious Diseases, 11 (3), ofae121. https://doi.org/10.1093/ofid/ofae121.
dc.identifier.issn2328-8957es
dc.identifier.urihttps://hdl.handle.net/11441/157043
dc.description.abstractBackground. Several aspects of the occurrence and management of mycotic aneurysm (MA) in patients with infective endocarditis (IE) have not been studied. Objectives. To determine the incidence and factors associated with MA presence and rupture and to assess the evolution of those initially unruptured MA. Methods. Prospective multicenter cohort including all patients with definite IE between January 2008 and December 2020. Results. Of 4548 IE cases, 85 (1.9%) developed MA. Forty-six (54.1%) had intracranial MA and 39 (45.9%) extracranial MA. Rupture of MA occurred in 39 patients (45.9%). Patients with ruptured MA had higher 1-year mortality (hazard ratio, 2.33; 95% confidence interval, 1.49–3.67). Of the 55 patients with initially unruptured MA, 9 (16.4%) presented rupture after a median of 3 days (interquartile range, 1–7) after diagnosis, being more frequent in intracranial MA (32% vs 3.3%, P = .004). Of patients with initially unruptured MA, there was a trend toward better outcomes among those who received early specific intervention, including lower follow-up rupture (7.1% vs 25.0%, P = .170), higher rate of aneurysm resolution in control imaging (66.7% vs 31.3%, P = .087), lower MA-related mortality (7.1% vs 16.7%, P = .232), and lower MA-related sequalae (0% vs 27.8%, P = .045). Conclusions. MA occurred in 2% of the patients with IE. Half of the Mas occurred in an intracranial location. Their rupture is frequent and associated with poor prognosis. A significant proportion of initially unruptured aneurysms result from rupture during the first several days, being more common in intracranial aneurysms. Early specific treatment could potentially lead to better outcomeses
dc.formatapplication/pdfes
dc.format.extent11 p.es
dc.language.isoenges
dc.publisherOxford Univ Presses
dc.relation.ispartofOpen Forum Infectious Diseases, 11 (3), ofae121.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectComplicationses
dc.subjectEpidemiologyes
dc.subjectInfective endocarditises
dc.subjectMortalityes
dc.subjectMycotic aneurysmes
dc.titleEpidemiology and risk factors of mycotic aneurysm in patients with infective endocarditis and the impact of its rupture in outcomes. Analysis of a national prospective cohortes
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Cirugíaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Microbiologíaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.relation.publisherversionhttps://academic.oup.com/ofid/article/11/3/ofae121/7628283es
dc.identifier.doi10.1093/ofid/ofae121es
dc.journaltitleOpen Forum Infectious Diseaseses
dc.publication.volumen11es
dc.publication.issue3es
dc.publication.initialPageofae121es

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