dc.creator | Calderón-Parra, Jorge | es |
dc.creator | Domínguez, Fernando | es |
dc.creator | González-Rico, Claudia | es |
dc.creator | Arnaiz de las Revillas, Francisco | es |
dc.creator | Goenaga, Miguel Ángel | es |
dc.creator | Álvarez, I. | es |
dc.creator | Muñoz, Patricia | es |
dc.creator | Alonso, David | es |
dc.creator | Rodríguez-García, Raquel | es |
dc.creator | Miró, José María | es |
dc.creator | Spanish Collaboration on Endocarditis (GAMES) | es |
dc.creator | Araji Tiliani, Omar | es |
dc.creator | Cueto López, Marina de | es |
dc.creator | Gutiérrez Carretero, Encarnación | es |
dc.creator | Lepe Jiménez, José Antonio | es |
dc.creator | López-Cortes, Luis Eduardo | es |
dc.date.accessioned | 2024-04-23T14:10:10Z | |
dc.date.available | 2024-04-23T14:10:10Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Calderón-Parra, J., Domínguez, F., González-Rico, C., Arnaiz de las Revillas, F., Goenaga, M.Á., Álvarez, I.,...,López-Cortes, L.E. (2024). Epidemiology and risk factors of mycotic aneurysm in patients with infective endocarditis and the impact of its rupture in outcomes. Analysis of a national prospective cohort. Open Forum Infectious Diseases, 11 (3), ofae121. https://doi.org/10.1093/ofid/ofae121. | |
dc.identifier.issn | 2328-8957 | es |
dc.identifier.uri | https://hdl.handle.net/11441/157043 | |
dc.description.abstract | Background. Several aspects of the occurrence and management of mycotic aneurysm (MA) in patients with infective
endocarditis (IE) have not been studied.
Objectives. To determine the incidence and factors associated with MA presence and rupture and to assess the evolution of
those initially unruptured MA.
Methods. Prospective multicenter cohort including all patients with definite IE between January 2008 and December 2020.
Results. Of 4548 IE cases, 85 (1.9%) developed MA. Forty-six (54.1%) had intracranial MA and 39 (45.9%) extracranial MA.
Rupture of MA occurred in 39 patients (45.9%). Patients with ruptured MA had higher 1-year mortality (hazard ratio, 2.33; 95%
confidence interval, 1.49–3.67). Of the 55 patients with initially unruptured MA, 9 (16.4%) presented rupture after a median of 3
days (interquartile range, 1–7) after diagnosis, being more frequent in intracranial MA (32% vs 3.3%, P = .004). Of patients with
initially unruptured MA, there was a trend toward better outcomes among those who received early specific intervention,
including lower follow-up rupture (7.1% vs 25.0%, P = .170), higher rate of aneurysm resolution in control imaging (66.7% vs
31.3%, P = .087), lower MA-related mortality (7.1% vs 16.7%, P = .232), and lower MA-related sequalae (0% vs 27.8%, P = .045).
Conclusions. MA occurred in 2% of the patients with IE. Half of the Mas occurred in an intracranial location. Their rupture is
frequent and associated with poor prognosis. A significant proportion of initially unruptured aneurysms result from rupture during
the first several days, being more common in intracranial aneurysms. Early specific treatment could potentially lead to better outcomes | es |
dc.format | application/pdf | es |
dc.format.extent | 11 p. | es |
dc.language.iso | eng | es |
dc.publisher | Oxford Univ Press | es |
dc.relation.ispartof | Open Forum Infectious Diseases, 11 (3), ofae121. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Complications | es |
dc.subject | Epidemiology | es |
dc.subject | Infective endocarditis | es |
dc.subject | Mortality | es |
dc.subject | Mycotic aneurysm | es |
dc.title | Epidemiology and risk factors of mycotic aneurysm in patients with infective endocarditis and the impact of its rupture in outcomes. Analysis of a national prospective cohort | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Cirugía | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Microbiología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://academic.oup.com/ofid/article/11/3/ofae121/7628283 | es |
dc.identifier.doi | 10.1093/ofid/ofae121 | es |
dc.journaltitle | Open Forum Infectious Diseases | es |
dc.publication.volumen | 11 | es |
dc.publication.issue | 3 | es |
dc.publication.initialPage | ofae121 | es |