dc.creator | García Cañas, Raquel María | es |
dc.creator | Giner Lamia, Joaquín | es |
dc.creator | Florencio Bellido, Francisco Javier | es |
dc.creator | López Maury, Luis | es |
dc.date.accessioned | 2024-03-21T08:42:28Z | |
dc.date.available | 2024-03-21T08:42:28Z | |
dc.date.issued | 2021-01-25 | |
dc.identifier.citation | García Cañas, R.M., Giner Lamia, J., Florencio Bellido, F.J. y López Maury, L. (2021). A protease-mediated mechanism regulates the cytochrome c6/plastocyanin switch in Synechocystis sp. PCC 6803. PNAS, 118 (5), e2017898118. https://doi.org/10.1073/pnas.2017898118. | |
dc.identifier.issn | 0027-8424 | es |
dc.identifier.issn | 1091-6490 | es |
dc.identifier.uri | https://hdl.handle.net/11441/156450 | |
dc.description.abstract | After the Great Oxidation Event (GOE), iron availability was greatly decreased, and photosynthetic organisms evolved several alternative proteins and mechanisms. One of these proteins, plastocyanin, is a type I blue-copper protein that can replace cytochrome c6 as a soluble electron carrier between cytochrome b6f and photosystem I. In most cyanobacteria, expression of these two alternative proteins is regulated by copper availability, but the regulatory system remains unknown. Herein, we provide evidence that the regulatory system is composed of a BlaI/CopY-family transcription factor (PetR) and a BlaR-membrane protease (PetP). PetR represses petE (plastocyanin) expression and activates petJ (cytochrome c6), while PetP controls PetR levels in vivo. Using whole-cell extracts, we demonstrated that PetR degradation requires both PetP and copper. Transcriptomic analysis revealed that the PetRP system regulates only four genes (petE, petJ, slr0601, and slr0602), highlighting its specificity. Furthermore, the presence of petE and petRP in early branching cyanobacteria indicates that acquisition of these genes could represent an early adaptation to decreased iron bioavailability following the GOE. | es |
dc.description.sponsorship | Ministerio de Economía y Competividad BIO2016-75634-P | es |
dc.description.sponsorship | Agencia Estatal de Investigación PID2019-104513GB-I00 | es |
dc.description.sponsorship | Junta de Andalucía Group BIO-284, cofinanced by European Regional Funds | es |
dc.format | application/pdf | es |
dc.format.extent | 10 p. | es |
dc.language.iso | eng | es |
dc.publisher | NAS | es |
dc.relation.ispartof | PNAS, 118 (5), e2017898118. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | cyanobacteria | es |
dc.subject | Cytochrome c6 | es |
dc.subject | Plastocyanin | es |
dc.title | A protease-mediated mechanism regulates the cytochrome c6/plastocyanin switch in Synechocystis sp. PCC 6803 | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular | es |
dc.relation.projectID | BIO2016-75634-P | es |
dc.relation.projectID | PID2019-104513GB-I00 | es |
dc.relation.projectID | BIO-284 | es |
dc.relation.publisherversion | https://dx.doi.org/10.1073/pnas.2017898118 | es |
dc.identifier.doi | 10.1073/pnas.2017898118 | es |
dc.journaltitle | PNAS | es |
dc.publication.volumen | 118 | es |
dc.publication.issue | 5 | es |
dc.publication.initialPage | e2017898118 | es |
dc.contributor.funder | Ministerio de Economia, Industria y Competitividad (MINECO). España | es |
dc.contributor.funder | Agencia Estatal de Investigación. España | es |
dc.contributor.funder | Junta de Andalucía | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |
dc.description.awardwinning | Premio Anual Publicación Científica Destacada de la US. Facultad de Biología | |