dc.creator | Maldonado y Aibar, María Dolores | es |
dc.creator | Mora Santos, María del Mar | es |
dc.creator | Naji, L. | es |
dc.creator | Carrascosa-Salmoral, M. P. | es |
dc.creator | Naranjo, M. C. | es |
dc.creator | Calvo Gutiérrez, Juan Ramón | es |
dc.date.accessioned | 2024-02-19T14:41:14Z | |
dc.date.available | 2024-02-19T14:41:14Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Maldonado y Aibar, M.D., Mora Santos, M.d.M., Naji, L., Carrascosa-Salmoral, M.P., Naranjo, M.C. y Calvo Gutiérrez, J.R. (2010). Evidence of melatonin synthesis and release by mast cells. Possible modulatory role on inflammation. Pharmacological Research, 62 (3), 282-287. https://doi.org/10.1016/j.phrs.2009.11.014. | |
dc.identifier.issn | 1043-6618 | es |
dc.identifier.uri | https://hdl.handle.net/11441/155348 | |
dc.description.abstract | Mast cells take part of armamentarium immunologic for host defense against parasitic and bacterial
infections. They are derived from bone marrow progenitors and can be activated by immunological and
chemical stimuli in order to get its degranulation. The activation of mast cells generates a signalling
cascade leaded to the rapid release of vasoactives and pro-inflammatory mediators. Melatonin (N-acetyl5-methoxytryptamine) is a molecule with antioxidant, cytoprotective and immunomodulatory actions.
It was initially known to be produced exclusively in the pineal gland but melatonin synthesis has been
found in different sites of the organism, and a major source of extrapineal melatonin is the immune
system. The aim of the present study was to prove if the rat mast cell line (RBL-2H3) synthesizes and
releases melatonin, also to explain its possible mechanism of action. We report that both resting and
stimulated mast cells synthesize and release melatonin. We also report that the necessary machinery
to synthesize melatonin is present in mast cells and that these cells showed the presence of MT1 and
MT2 melatonin membrane receptors. Those results indicated that the melatonin would be able to exert
a regulatory effect on inflammatory reactions mediated by mast cells. | es |
dc.format | application/pdf | es |
dc.format.extent | 6 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Pharmacological Research, 62 (3), 282-287. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Melatonin | es |
dc.subject | Mast cells | es |
dc.subject | Cytokines | es |
dc.subject | Inflammation | es |
dc.subject | NAT and HIOMT | es |
dc.title | Evidence of melatonin synthesis and release by mast cells. Possible modulatory role on inflammation | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Microbiología | es |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S1043661809002837?via%3Dihub | es |
dc.identifier.doi | 10.1016/j.phrs.2009.11.014 | es |
dc.journaltitle | Pharmacological Research | es |
dc.publication.volumen | 62 | es |
dc.publication.issue | 3 | es |
dc.publication.initialPage | 282 | es |
dc.publication.endPage | 287 | es |