Artículo
3D printed systems for colon-specific delivery of camptothecin-loaded chitosan micelles
Autor/es | Almeida, Andreia
Linares Blasco, Vicente Mora Castaño, Gloria Casas Delgado, Marta ![]() ![]() ![]() ![]() ![]() ![]() Caraballo Rodríguez, Isidoro ![]() ![]() ![]() ![]() ![]() ![]() ![]() Sarmento, Bruno |
Departamento | Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica |
Fecha de publicación | 2021-10 |
Fecha de depósito | 2024-02-07 |
Publicado en |
|
Resumen | The use of 3D printing technology in the manufacturing of drug delivery systems has expanded and benefit of a customized care. The ability to create tailor-made structures filled with drugs/delivery systems with suitable ... The use of 3D printing technology in the manufacturing of drug delivery systems has expanded and benefit of a customized care. The ability to create tailor-made structures filled with drugs/delivery systems with suitable drug dosage is especially appealing in the field of nanomedicine. In this work, chitosan-based polymeric micelles loaded with camptothecin (CPT) were incorporated into 3D printing systems (printfills) sealed with an enteric layer, aiming to protect the nanosystems from the harsh environment of the gastrointestinal tract (GIT). Polymeric micelles and printfills were fully characterized and, a simulated digestion of the 3D systems upon an oral administration was performed. The printfills maintained intact at the simulated gastric pH of the stomach and, only released the micelles at the colonic pH. From there, the dissolution media was used to recreate the intestinal absorption and, chitosan micelles showed a significant increase of the CPT permeability compared to the free drug, reaching an apparent permeability coefficient (Papp) of around 9×10-6 cm/s in a 3D intestinal cell-based model. The combination of 3D printing with nanotechnology appears to have great potential for the colon-specific release of polymeric micelles, thereby increasing intestinal absorption while protecting the system/drug from degradation throughout the GIT. |
Agencias financiadoras | Ministério da Ciência, Tecnologia e Ensino Superior. Portugal Plataforma Portuguesa de Bioimagem Ministerio de Ciencia, Innovación y Universidades (MICINN). España |
Identificador del proyecto | UID/BIM/04293/2019
![]() POCI-01-0145-FEDER-022122 ![]() RTI2018-095041-B-C31 ![]() |
Cita | Almeida, A., Linares Blasco, V., Mora Castaño, G., Casas Delgado, M., Caraballo Rodríguez, I. y Sarmento, B. (2021). 3D printed systems for colon-specific delivery of camptothecin-loaded chitosan micelles. European Journal of Pharmaceutics and Biopharmaceutics, 167, 48-56. https://doi.org/10.1016/j.ejpb.2021.07.005. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
3D printed systems_C.pdf | 1.269Mb | ![]() | Ver/ | Versión aceptada |
Supplementary material_3D printed ... | 573.7Kb | ![]() | Ver/ | Versión aceptada |