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An Efficient and Practical Method for the Enantioselective Synthesis of Tertiary Trifluoromethyl Carbinols
dc.creator | Borrego Sánchez de la Cuesta, Lorenzo Gabriel | es |
dc.creator | Recio Jiménez, Rocío | es |
dc.creator | Alcarranza Saucedo, Manuel | es |
dc.creator | Khiar, Noureddine | es |
dc.creator | Fernández Fernández, Inmaculada | es |
dc.date.accessioned | 2024-01-31T11:44:20Z | |
dc.date.available | 2024-01-31T11:44:20Z | |
dc.date.issued | 2018-03 | |
dc.identifier.citation | Borrego Sánchez de la Cuesta, L.G., Recio Jiménez, R., Alcarranza Saucedo, M., Khiar, N. y Fernández Fernández, I. (2018). An Efficient and Practical Method for the Enantioselective Synthesis of Tertiary Trifluoromethyl Carbinols. Advanced Synthesis and Catalysis, 360 (6), 1273-1279. https://doi.org/10.1002/adsc.201701212. | |
dc.identifier.issn | 1615-4150 | es |
dc.identifier.uri | https://hdl.handle.net/11441/154332 | |
dc.description.abstract | An efficient sulfinamide/olefin based chiral ligand, MetSulfolefin, has been developed for the enantioselective rhodium-catalysed addition of aryl-boronic acids to trifluoromethyl ketones. This shelf-stable ligand is insensitive to air, oxygen and moisture, and it is obtained in only two high yielding steps from cheap commercially available (R)-tert-butanesulfinamide. The new ligand tolerates the use of hindered boronic acids and leads to the formation of a series of chiral trifluoromethyl-substituted tertiary carbinols in high yields and excellent enantioselectivities (up to >99% ee). (Figure presented.). | es |
dc.format | application/pdf | es |
dc.format.extent | 7 p. | es |
dc.language.iso | eng | es |
dc.publisher | Wiley Online Library | es |
dc.relation.ispartof | Advanced Synthesis and Catalysis, 360 (6), 1273-1279. | |
dc.subject | Tertiary trifluoromethyl carbinols | es |
dc.subject | Chi-ral sulfinamide-olefin | es |
dc.subject | Enantioselective rhodium-catalysed arylation | es |
dc.subject | Shelf-stable ligand | es |
dc.subject | Cost effec-tive synthetic approximation | es |
dc.title | An Efficient and Practical Method for the Enantioselective Synthesis of Tertiary Trifluoromethyl Carbinols | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología | es |
dc.relation.projectID | CTQ2016-78580-C2-2-R | es |
dc.relation.projectID | CTQ2016-78580-C2-1-R | es |
dc.relation.projectID | 11-FQM-08046 | es |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1002/adsc.201701212 | es |
dc.identifier.doi | 10.1002/adsc.201701212 | es |
dc.journaltitle | Advanced Synthesis and Catalysis | es |
dc.publication.volumen | 360 | es |
dc.publication.issue | 6 | es |
dc.publication.initialPage | 1273 | es |
dc.publication.endPage | 1279 | es |
dc.contributor.funder | Ministerio de Economía y Competitividad (MINECO). España | es |
dc.contributor.funder | Junta de Andalucía | es |
dc.description.awardwinning | Premio Mensual Publicación Científica Destacada de la US. Facultad de Farmacia |
Ficheros | Tamaño | Formato | Ver | Descripción |
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10.1002_adsc.201701212.pdf | 884.7Kb | ![]() | Ver/ | Versión Aceptada |
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