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Artículo
Immunomodulatory Response of Toll-like Receptor Ligand-Peptide Conjugates in Food Allergy
dc.contributor.advisor | ||
dc.creator | Losada Méndez, Jorge | es |
dc.creator | Palomares, Francisca | es |
dc.creator | Gómez, Francisca | es |
dc.creator | Ramírez-López, Pedro | es |
dc.creator | Ramos-Soriano, Javier | es |
dc.creator | Torres, Maria Jose | es |
dc.creator | Rojo, Javier | es |
dc.date.accessioned | 2024-01-25T15:55:57Z | |
dc.date.available | 2024-01-25T15:55:57Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 1554-8929 | |
dc.identifier.issn | 1554-8937 | |
dc.identifier.uri | https://hdl.handle.net/11441/154033 | |
dc.description.abstract | Covalent conjugation of allergens to toll-like receptor (TLR) agonists appears to be a powerful strategy for the development of safety compounds for allergen-specific immunomodulatory response toward tolerance in allergy. In this work, we have synthesized two family of ligands, an 8-oxoadenine derivative as a ligand for TLR7 and a pyrimido[5,4-b]indole as a ligand for TLR4, both conjugated with a T-cell peptide of Pru p 3 allergen, the lipid transfer protein (LTP) responsible for LTP-dependent food allergy. These conjugates interact with dendritic cells, inducing their specific maturation, T-cell proliferation, and cytokine production in peach allergic patients. Moreover, they increased the Treg-cell frequencies in these patients and could induce the IL-10 production. These outcomes were remarkable in the case of the TLR7 ligand conjugated with Pru p 3, opening the door for the potential application of these allergen–adjuvant systems in food allergy immunotherapy. | es |
dc.format | application/pdf | es |
dc.format.extent | 14 p. | es |
dc.language.iso | eng | es |
dc.publisher | American Chemical Society. | es |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Immunomodulatory Response of Toll-like Receptor Ligand-Peptide Conjugates in Food Allergy | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.relation.publisherversion | https://pubs.acs.org/doi/10.1021/acschembio.1c00765 | es |
dc.identifier.doi | 10.1021/acschembio.1c00765 | es |
dc.journaltitle | acs Chemical Biology | es |
dc.publication.volumen | 16 | es |
dc.publication.issue | 11 | es |
dc.publication.initialPage | 2651 | es |
dc.publication.endPage | 2669 | es |