Artículo
Total and Fetal Circulating Cell-Free DNA, Angiogenic, and Antiangiogenic Factors in Preeclampsia and HELLP Syndrome
Autor/es | Muñoz Hernández, Rocío
Medrano Campillo, Pablo Miranda Guisado, María Luisa Macher, Hada C. Praena Fernández, Juan Manuel Vallejo Vaz, Antonio Javier Domínguez Simeón, María J. Moreno Luna, Rafael Stiefel García-Junco, Pablo Enrique |
Departamento | Universidad de Sevilla. Departamento de Fisiología Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2017 |
Fecha de depósito | 2024-01-24 |
Publicado en |
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Resumen | BACKGROUND
Preeclampsia (PE) is a hypertensive disorder of pregnancy characterized by hypertension and proteinuria. The HELLP syndrome is the most severe form of PE. The aim of the present study was to determine different ... BACKGROUND Preeclampsia (PE) is a hypertensive disorder of pregnancy characterized by hypertension and proteinuria. The HELLP syndrome is the most severe form of PE. The aim of the present study was to determine different potential biomarkers that may help us perform an early diagnosis of the disease, assess on the severity of the disease, and/or predict maternal or fetal adverse outcomes. METHODS We measured serum levels of total and fetal circulating cell-free DNA (cfDNA), soluble endoglin, soluble form of vascular endothelial growth factor receptor, and placental growth factor in a healthy control group of pregnant women (n = 26), patients with mild (n = 37) and severe PE (n = 25), and patients with HELLP syndrome (n = 16). RESULTS We observed a gradual and strong relationship between all the biomarkers mentioned and the range of severity of PE, with the highest levels in patients with HELLP syndrome. Nevertheless, only the values of total cfDNA were able to significantly differentiate severe PE and HELLP syndrome (20957 ± 2784 vs. 43184 ± 8647 GE/ml, P = 0.01). Receiver operating characteristic (ROC) curves were constructed (i) for the healthy group with respect to the groups with PE and (ii) for patients with PE with respect to the group with HELLP syndrome; sensitivity and specificity values at different cutoff levels were calculated in each case. The maximum ROC area under the curve value for PE and HELLP syndrome (with respect to controls) was 0.91 (P < 0.001). CONCLUSIONS The measured biomarkers of cell damage, angiogenesis, and antiangiogenesis may reflect the severity of PE, with higher levels in patients who develop HELLP syndrome. In addition, these biomarkers may also help predict adverse fetal and maternal outcomes. |
Agencias financiadoras | Junta de Andalucía Instituto de Salud Carlos III |
Identificador del proyecto | PI-0082- 2012
PI10/02473 |
Cita | Muñoz Hernández, R., Medrano Campillo, P., Miranda Guisado, M.L., Macher, H.C., Praena Fernández, J.M., Vallejo Vaz, A.J.,...,Stiefel García-Junco, P.E. (2017). Total and Fetal Circulating Cell-Free DNA, Angiogenic, and Antiangiogenic Factors in Preeclampsia and HELLP Syndrome. American Journal of Hypertension, 30 (7), 673-682. https://doi.org/10.1093/ajh/hpx024. |
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