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dc.creatorMannini, Benedettaes
dc.creatorVecchi, Giuliaes
dc.creatorLabrador Garrido, Adahires
dc.creatorFabre, Bertrandes
dc.creatorPozo Pérez, Davides
dc.creatorDobson, Christopher M.es
dc.creatorRoodveldt, Cintiaes
dc.date.accessioned2024-01-19T12:10:34Z
dc.date.available2024-01-19T12:10:34Z
dc.date.issued2019
dc.identifier.citationMannini, B., Vecchi, G., Labrador Garrido, A., Fabre, B., Pozo Pérez, D., Dobson, C.M., Roodveldt, C. y Roodveldt, C. (2019). Differential Interactome and Innate Immune Response Activation of Two Structurally Distinct Misfolded Protein Oligomers. ACS Chemical Neuroscience, 18 (8), 3464-3478. https://doi.org/0.1021/acschemneuro.9b00088..
dc.identifier.issn1948-7193es
dc.identifier.urihttps://hdl.handle.net/11441/153653
dc.description.abstractThe formation of misfolded protein oligomers during early stages of amyloid aggregation and the activation of neuroinflammatory responses are two key events associated with neurodegenerative diseases. Although it has been established that misfolded oligomers are involved in the neuroinflammatory process, the links between their structural features and their functional effects on the immune response remain unknown. To explore such links, we took advantage of two structurally distinct soluble oligomers (type A and B) of protein HypF-N and compared the elicited microglial inflammatory responses. By using confocal microscopy, protein pull-down, and high-throughput mass spectrometry, we found that, even though both types bound to a common pool of microglial proteins, type B oligomers—with a lower solvent-exposed hydrophobicity—showed enhanced protein binding, correlating with the observed inflammatory response. Furthermore, the interactome associated with inflammatory-mediated neurodegeneration revealed previously unidentified receptors and signaling molecules likely to be involved in the oligomer-elicited innate immune response.es
dc.formatapplication/pdfes
dc.language.isoenges
dc.publisherAmerican Chemical Societyes
dc.relation.ispartofACS Chemical Neuroscience, 18 (8), 3464-3478.
dc.subjectMisfolded oligomerses
dc.subjectprotein misfoldinges
dc.subjectneuroinflammationes
dc.subjectneurodegenerative diseasees
dc.subjectinnate immunityes
dc.subjectmolecular mechanismses
dc.titleDifferential Interactome and Innate Immune Response Activation of Two Structurally Distinct Misfolded Protein Oligomerses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioneu-repo/semantics/acceptedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunologíaes
dc.relation.projectIDASTF 450-2013es
dc.relation.projectIDRYC-2017-23127es
dc.relation.projectIDP11-CTS-8161es
dc.relation.projectIDPAIDI2020 CTS-677es
dc.relation.projectIDRTC-2015-3309-1es
dc.relation.projectIDISCIII CPII16/58es
dc.relation.projectIDPI14-1600es
dc.relation.projectIDRTI2018-098432-B-I00es
dc.date.embargoEndDate2020-07-17
dc.relation.publisherversionhttps://pubs.acs.org/doi/10.1021/acschemneuro.9b00088es
dc.identifier.doi0.1021/acschemneuro.9b00088.es
dc.journaltitleACS Chemical Neurosciencees
dc.publication.volumen18es
dc.publication.issue8es
dc.publication.initialPage3464es
dc.publication.endPage3478es
dc.contributor.funderCambridge Centre for Misfolding Diseaseses
dc.contributor.funderEMBOes
dc.contributor.funderFEBS (Short-Term Fellowship)es
dc.contributor.funderItalian Society of Biochemistry and Molecular Biologyes
dc.contributor.funderPrograma "Atraccion de Talento", University of Sevillees
dc.contributor.funderPrograma "Ramon y Cajal", Spanish Ministry of Economyes
dc.contributor.funderRegional Ministry of Economyes
dc.contributor.funderSpanish Ministry of Economyes

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