dc.creator | Gavilán Dorronzoro, Elena | es |
dc.creator | Medina Guzmán, Rafael | es |
dc.creator | Bahatyrevich Kharitonik, Bazhena | es |
dc.creator | Ruano Caballero, Diego | es |
dc.date.accessioned | 2024-01-17T07:38:26Z | |
dc.date.available | 2024-01-17T07:38:26Z | |
dc.date.issued | 2024-01-09 | |
dc.identifier.citation | Gavilán Dorronzoro, E., Medina Guzmán, R., Bahatyrevich Kharitonik, B. y Ruano Caballero, D. (2024). Protein Quality Control Systems and ER Stress as Key Players in SARS-CoV-2-Induced Neurodegeneration. Cells, 13 (2), 123. https://doi.org/10.3390/cells13020123. | |
dc.identifier.issn | 2073-4409 | es |
dc.identifier.uri | https://hdl.handle.net/11441/153486 | |
dc.description.abstract | The COVID-19 pandemic has brought to the forefront the intricate relationship between
SARS-CoV-2 and its impact on neurological complications, including potential links to neurodegenerative
processes, characterized by a dysfunction of the protein quality control systems and ER
stress. This review article explores the role of protein quality control systems, such as the Unfolded
Protein Response (UPR), the Endoplasmic Reticulum-Associated Degradation (ERAD), the Ubiquitin–
Proteasome System (UPS), autophagy and the molecular chaperones, in SARS-CoV-2 infection. Our
hypothesis suggests that SARS-CoV-2 produces ER stress and exploits the protein quality control
systems, leading to a disruption in proteostasis that cannot be solved by the host cell. This disruption
culminates in cell death and may represent a link between SARS-CoV-2 and neurodegeneration. | es |
dc.format | application/pdf | es |
dc.format.extent | 32 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Cells, 13 (2), 123. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | COVID-19 | es |
dc.subject | SARS-CoV-2 | es |
dc.subject | protein quality control systems | es |
dc.subject | ER stress | es |
dc.subject | neurodegeneration | es |
dc.title | Protein Quality Control Systems and ER Stress as Key Players in SARS-CoV-2-Induced Neurodegeneration | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular | es |
dc.relation.publisherversion | https://doi.org/10.3390/cells13020123 | es |
dc.identifier.doi | 10.3390/cells13020123 | es |
dc.journaltitle | Cells | es |
dc.publication.volumen | 13 | es |
dc.publication.issue | 2 | es |
dc.publication.initialPage | 123 | es |