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A New Microchip Design. A Versatile Combination of Electromembrane Extraction and Liquid-Phase Microextraction in a Single Chip Device
dc.creator | Ramos Payán, María Dolores | es |
dc.creator | Santigosa, Elia | es |
dc.creator | Fernández Torres, Rut | es |
dc.creator | Bello López, Miguel Ángel | es |
dc.date.accessioned | 2024-01-10T12:32:50Z | |
dc.date.available | 2024-01-10T12:32:50Z | |
dc.date.issued | 2018-08-09 | |
dc.identifier.citation | Ramos Payán, M.D., Santigosa, E., Fernández Torres, R. y Bello López, M.Á. (2018). A New Microchip Design. A Versatile Combination of Electromembrane Extraction and Liquid-Phase Microextraction in a Single Chip Device. Analytical Chemistry, 90 (17), 10417-10424. https://doi.org/10.1021/acs.analchem.8b02292. | |
dc.identifier.issn | 0003-2700 | es |
dc.identifier.issn | 1520-6882 | es |
dc.identifier.uri | https://hdl.handle.net/11441/153166 | |
dc.description.abstract | For thefirst time, a novel and versatile microfluidic device wasdeveloped to achieve the possibility of combining different extraction principlesusing a miniaturized approach for the extraction of different classes of analytes.This novel microchip is composed of a sandwich of three poly(methylmethacrylate) (PMMA) layers. Four channels allowed the combination ofelectromembrane extraction (EME) and liquid-phase microextraction (LPME) inthree different ways: (I) EME and LPME, (II) EME and EME, or (III) LPME andLPME. The microchip can be used either (a) using a common acceptor phase (forboth extractions) for the simultaneous extraction of drugs from different nature in asingle step, or (b) a common sample solution (for both extractions) and twoacceptor solutions for simultaneous drug separation. In this work, the performanceof this novel microchip was demonstrated by simultaneous integration of EME andLPME using a common acceptor phase for both extractions. This configurationreduces the time of analysis allowing direct analysis in a single chip. The microchip was tested for extracting two different classesof analytes:fivefluoroquinolones and four parabens as model analytes. All effective variables were optimized for EME andLPME. Under the optimized conditions, the reusable microchip enables simultaneousμ-EME/LPME with extractionefficiencies over 77% in only 8 min extraction and sample volume consumption lower than 40μL. The optimized procedure wassuccessfully applied to urine samples obtaining recoveries over 90% for all analytes. | es |
dc.description.sponsorship | Ministerio de Educación y Ciencia, España, Dirección General de Investigación y Gestión del Plan Nacional de I+D+I - TEC2006-79367-C2-1-R | es |
dc.format | application/pdf | es |
dc.format.extent | 8 p. | es |
dc.language.iso | eng | es |
dc.publisher | American Chemical Society | es |
dc.relation.ispartof | Analytical Chemistry, 90 (17), 10417-10424. | |
dc.title | A New Microchip Design. A Versatile Combination of Electromembrane Extraction and Liquid-Phase Microextraction in a Single Chip Device | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química Analítica | es |
dc.relation.projectID | TEC2006-79367-C2-1-R | es |
dc.relation.publisherversion | https://doi.org/10.1021/acs.analchem.8b02292 | es |
dc.identifier.doi | 10.1021/acs.analchem.8b02292 | es |
dc.journaltitle | Analytical Chemistry | es |
dc.publication.volumen | 90 | es |
dc.publication.issue | 17 | es |
dc.publication.initialPage | 10417 | es |
dc.publication.endPage | 10424 | es |
dc.contributor.funder | Ministerio de Educación y Ciencia (MEC). España | es |
dc.description.awardwinning | Premio Anual Publicación Científica Destacada de la US. Facultad de Química |
Ficheros | Tamaño | Formato | Ver | Descripción |
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Manuscript_New Microchip desig ... | 1.063Mb | ![]() | Ver/ | Versión aceptada |
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