Artículo
Maternal selenium status is profoundly involved in metabolic fetal programming by modulating insulin resistance, oxidative balance and energy homeostasis
Autor/es | Ojeda Murillo, María Luisa
Nogales Bueno, Fátima Membrilla Esteban, Alba Carreras Sánchez, Olimpia |
Departamento | Universidad de Sevilla. Departamento de Fisiología |
Fecha de publicación | 2019-12 |
Fecha de depósito | 2023-12-27 |
Publicado en |
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Resumen | Abstract
Purpose High and low levels of selenium (Se) have been related to metabolic disorders in dams and in their offspring. Their
relationship to oxidative balance and to AMP-activated protein kinase (AMPK) is some ... Abstract Purpose High and low levels of selenium (Se) have been related to metabolic disorders in dams and in their offspring. Their relationship to oxidative balance and to AMP-activated protein kinase (AMPK) is some of the mechanisms proposed. The aim of this study is to acquire information about how Se is involved in metabolic programming. Methods Three experimental groups of dam rats were used: control (Se: 0.1 ppm), Se supplemented (Se: 0.5 ppm) and Se deficient (Se: 0.01 ppm). At the end of lactation, the pups’ metabolic profile, oxidative balance, Se levels, selenoproteins and IRS-1 hepatic expression, as well as hepatic AMPK activation were measured. Results The experimental groups present deep changes in Se homeostasis, selenoproteins and IRS-1 hepatic expression, oxidative balance, AMPK activation ratio and insulin levels. They do, however, have different metabolic profiles. Conclusions High- and low-Se diets are linked to insulin resistance, yet the mechanisms involved are completely opposite. |
Agencias financiadoras | Junta de Andalucía |
Identificador del proyecto | CTS-193 |
Cita | Ojeda Murillo, M.L., Nogales Bueno, F., Membrilla Esteban, A. y Carreras Sánchez, O. (2019). Maternal selenium status is profoundly involved in metabolic fetal programming by modulating insulin resistance, oxidative balance and energy homeostasis. European Journal of Nutrition, 58 (8), 3171-3181. https://doi.org/10.1007/s00394-018-1861-4. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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Manuscript Maternal Se EJON ... | 834.2Kb | [PDF] | Ver/ | Versión aceptada |
Figure Maternal Se EJON 2019.pdf | 657.2Kb | [PDF] | Ver/ | |
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