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dc.creatorSerrano Morales, José Manueles
dc.creatorVázquez Carretero, María Doloreses
dc.creatorPeral Rubio, María Josées
dc.creatorIlundáin Larrañeta, María Anunciación Anaes
dc.creatorGarcía Miranda, Pabloes
dc.date.accessioned2023-11-30T16:19:22Z
dc.date.available2023-11-30T16:19:22Z
dc.date.issued2017
dc.identifier.citationSerrano Morales, J.M., Vázquez Carretero, M.D., Peral Rubio, M.J., Ilundáin Larrañeta, M.A.A. y García Miranda, P. (2017). Reelin-Dab1 signaling system in human colorectal cancer. Molecular Carcinogenesis, 56 (2), 712-721. https://doi.org/10.1002/mc.22527.
dc.identifier.issn0899-1987es
dc.identifier.issn1098-2744es
dc.identifier.urihttps://hdl.handle.net/11441/151982
dc.description.abstractReelin is an extracellular matrix protein that plays a critical role in neuronal migration. Here we show that the mucosa of human colon expresses reelin, its receptors ApoER2 and VLDLR, and its effector protein Dab1. Immunohistochemical analyses reveal that reelin expression is restricted to pericryptal myofibroblasts; Dab1 is detected at myofibroblasts, the apical domain of surface epithelial and crypt cells, and a strong linear staining is observed at the basement membrane; VLDLR and ApoER2 are in the cytoplasm of surface epithelium and myofibroblasts, and VLDLR is also detected in the cytoplasm of the crypt cells. Human colorectal cancer downregulates reelin without change in vimentin or N-cadherin mRNA levels. Decreased Reelin mRNA expression is accompanied by decreased HIC1 mRNA levels, increased mRNA levels of ApoER2 and DNMT1, increased reelin hypermethylation and no change in either Cask or TGF-β1 mRNAs, suggesting that reelin repression results from a DNMT1-mediated hypermethylation of the reelin gene promoter. Decreased HIC1 expression may repress reelin transcription via increasing ApoER2 transcription. We conclude that the mucosa of human colon expresses the reelin-Dab1 signaling system and that reelin is repressed in colorectal cancer before epithelial-mesenchymal transition has occurred. The significant down-regulation of reelin expression makes this gene a promising biomarker for colorectal cancers.es
dc.description.sponsorshipJunta de Andalucía CTS 5884es
dc.formatapplication/pdfes
dc.format.extent20 p.es
dc.language.isoenges
dc.publisherWiley-Blackwelles
dc.relation.ispartofMolecular Carcinogenesis, 56 (2), 712-721.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAdenocarcinomaes
dc.subjectApoER2es
dc.subjectCanceres
dc.subjectColones
dc.subjectReelines
dc.titleReelin-Dab1 signaling system in human colorectal canceres
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/acceptedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Fisiologíaes
dc.relation.projectIDCTS 5884es
dc.relation.publisherversionhttps://doi.org/10.1002/mc.22527es
dc.identifier.doi10.1002/mc.22527es
dc.journaltitleMolecular Carcinogenesises
dc.publication.volumen56es
dc.publication.issue2es
dc.publication.initialPage712es
dc.publication.endPage721es
dc.contributor.funderJunta de Andalucíaes

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