Mostrar el registro sencillo del ítem
Artículo
Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect
dc.creator | Rodriguez-Perez, MD | es |
dc.creator | Lopez-Villodres, JA | es |
dc.creator | Arrebola, MM | es |
dc.creator | Martin-Aurioles, E | es |
dc.creator | Fernández Prior, África | es |
dc.creator | Gonzalez-Correa, JA | es |
dc.date.accessioned | 2023-11-24T18:18:41Z | |
dc.date.available | 2023-11-24T18:18:41Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Rodriguez-Perez, M., Lopez-Villodres, J., Arrebola, M., Martin-Aurioles, E., Fernández Prior, Á. y Gonzalez-Correa, J. (2021). Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect. Antixidants, 10 (11), 1783. https://doi.org/10.3390/antiox10111783. | |
dc.identifier.issn | 2076-3921 | es |
dc.identifier.uri | https://hdl.handle.net/11441/151621 | |
dc.description.abstract | The aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg/kg/day p.o. for two months. After hydroxytyrosol administration, proteinuria was significantly reduced (67–73%), calculated creatinine clearance was significantly increased (26–38%), and the glomerular volume and glomerulosclerosis index were decreased (20–30%). Hydroxytyrosol reduced oxidative and nitrosative stress variables and thromboxane metabolite production. Statistical correlations were found between biochemical and kidney function variables. Oral administration of 1 and 5 mg/kg/day of hydroxytyrosol produced an antioxidant and nephroprotective effect in an experimental model of type 1-like diabetes mellitus. The nephroprotective effect was significantly associated with the systemic and renal antioxidant action of hydroxytyrosol, which also influenced eicosanoid production. | es |
dc.format | application/pdf | es |
dc.format.extent | 13 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI AG | es |
dc.relation.ispartof | Antixidants, 10 (11), 1783. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Hydroxytyrosol | es |
dc.subject | Diabetes | es |
dc.subject | Nephropathy | es |
dc.subject | Virgin olive oil | es |
dc.title | Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.relation.publisherversion | https://www.mdpi.com/2076-3921/10/11/1783 | es |
dc.identifier.doi | 10.3390/antiox10111783 | es |
dc.journaltitle | Antixidants | es |
dc.publication.volumen | 10 | es |
dc.publication.issue | 11 | es |
dc.publication.initialPage | 1783 | es |