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dc.creatorManouchehrian, O.es
dc.creatorRamos, M.es
dc.creatorBachiller, Saraes
dc.creatorLundgaard, I.es
dc.creatorDeierborg, T.es
dc.date.accessioned2023-11-24T17:56:11Z
dc.date.available2023-11-24T17:56:11Z
dc.date.issued2021
dc.identifier.issn1742-2094es
dc.identifier.urihttps://hdl.handle.net/11441/151620
dc.description.abstractThe exchange of cerebrospinal (CSF) and interstitial fluid is believed to be vital for waste clearance in the brain. The sleep-dependent glymphatic system, which is comprised of perivascular flow of CSF and is largely dependent on arterial pulsatility and astrocytic aquaporin-4 (AQP4) expression, facilitates much of this brain clearance. During the last decade, several observations have indicated that impaired glymphatic function goes hand in hand with neurodegenerative diseases. Since pathologies of the brain carry inflammatory components, we wanted to know how acute inflammation, e.g., with lipopolysaccharide (LPS) injections, would affect the glymphatic system. In this study, we aim to measure the effect of LPS on perivascular CSF distribution as a measure of glymphatic function.es
dc.formatapplication/pdfes
dc.format.extent13 p.es
dc.language.isoenges
dc.publisherBiomed Central LTDes
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAcute systemices
dc.subjectLPS-exposurees
dc.subjectPerivascular CSFes
dc.subjectMicees
dc.titleAcute systemic LPS-exposure impairs perivascular CSF distribution in micees
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunologíaes
dc.relation.publisherversionhttps://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-021-02082-6es
dc.identifier.doi10.1186/s12974-021-02082-6es
dc.journaltitleJournal of Neuroinflammationes
dc.publication.volumen18es
dc.publication.issue1es
dc.publication.initialPage34es

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Atribución 4.0 Internacional
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