dc.creator | Ojeda Murillo, María Luisa | es |
dc.creator | Nogales Bueno, Fátima | es |
dc.creator | Carrasco López, José Antonio | es |
dc.creator | Gallego López, María del Carmen | es |
dc.creator | Carreras Sánchez, Olimpia | es |
dc.creator | Alcudia Cruz, Ana | es |
dc.creator | Pajuelo Domínguez, Eloísa | es |
dc.date.accessioned | 2023-11-24T11:36:39Z | |
dc.date.available | 2023-11-24T11:36:39Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Ojeda Murillo, M.L., Nogales Bueno, F., Carrasco López, J.A., Gallego López, M.d.C., Carreras Sánchez, O., Alcudia Cruz, A. y Pajuelo Domínguez, E. (2023). Microbiota-liver-bile salts axis, a novel mechanism involved in the contrasting effects of sodium selenite and selenium-nanoparticle supplementation on adipose tissue development in adolescent rats. Antioxidants, 12 (5), 1123. https://doi.org/10.3390/antiox12051123. | |
dc.identifier.issn | 2076-3921 | es |
dc.identifier.uri | https://hdl.handle.net/11441/151560 | |
dc.description.abstract | Adolescence is a period during which body composition changes deeply. Selenium (Se)
is an excellent antioxidant trace element related to cell growth and endocrine function. In adolescent rats, low Se supplementation affects adipocyte development differently depending on its
form of administration (selenite or Se nanoparticles (SeNPs). Despite this effect being related to
oxidative, insulin-signaling and autophagy processes, the whole mechanism is not elucidated. The
microbiota–liver–bile salts secretion axis is related to lipid homeostasis and adipose tissue development. Therefore, the colonic microbiota and total bile salts homeostasis were explored in four
experimental groups of male adolescent rats: control, low-sodium selenite supplementation, low
SeNP supplementation and moderate SeNPs supplementation. SeNPs were obtained by reducing
Se tetrachloride in the presence of ascorbic acid. Supplementation was received orally through
water intake; low-Se rats received twice more Se than control animals and moderate-Se rats tenfold
more. Supplementation with low doses of Se clearly affected anaerobic colonic microbiota profile
and bile salts homeostasis. However, these effects were different depending on the Se administration form. Selenite supplementation primarily affected liver by decreasing farnesoid X receptor
hepatic function, leading to the accumulation of hepatic bile salts together to increase in the ratio
Firmicutes/Bacteroidetes and glucagon-like peptide-1 (GLP-1) secretion. In contrast, low SeNP
levels mainly affected microbiota, moving them towards a more prominent Gram-negative profile
in which the relative abundance of Akkermansia and Muribaculaceae was clearly enhanced and the
Firmicutes/Bacteroidetes ratio decreased. This bacterial profile is directly related to lower adipose
tissue mass. Moreover, low SeNP administration did not modify bile salts pool in serum circulation.
In addition, specific gut microbiota was regulated upon administration of low levels of Se in the forms
of selenite or SeNPs, which are properly discussed. On its side, moderate-SeNPs administration led
to great dysbiosis and enhanced the abundance of pathogenic bacteria, being considered toxic. These
results strongly correlate with the deep change in adipose mass previously found in these animals,
indicating that the microbiota–liver–bile salts axis is also mechanistically involved in these changes. | es |
dc.description.sponsorship | Junta de Andalucía y proyectos FEDER Andalucía de la Unión Europea - US-1380878 | es |
dc.description.sponsorship | Ministerio de Ciencia, Innovación y Universidades de Epaña - PID2019-109371GB-I00 | es |
dc.description.sponsorship | VII Plan Propio de Investigación y Transferencia de la Universidad de Sevilla US 2022 - 2022/00000332 y 2022/00000277 | es |
dc.format | application/pdf | es |
dc.format.extent | 23 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Antioxidants, 12 (5), 1123. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | selenite | es |
dc.subject | nanoparticles | es |
dc.subject | microbiota | es |
dc.subject | total bile salts | es |
dc.subject | GLP-1 | es |
dc.title | Microbiota-liver-bile salts axis, a novel mechanism involved in the contrasting effects of sodium selenite and selenium-nanoparticle supplementation on adipose tissue development in adolescent rats | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Microbiología y Parasitología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica | es |
dc.relation.projectID | US-1380878 | es |
dc.relation.projectID | PID2019-109371GB-I00 | es |
dc.relation.projectID | VII PP US 2022/00000332 | es |
dc.relation.projectID | VII PP US 2022/00000277 | es |
dc.relation.publisherversion | https://doi.org/10.3390/antiox12051123 | es |
dc.identifier.doi | 10.3390/antiox12051123 | es |
dc.contributor.group | Universidad de Sevilla. CTS193: Implicación del Balance Oxidativo en la Salud: Alcoholismo y Síndrome Metabólico. | es |
dc.journaltitle | Antioxidants | es |
dc.publication.volumen | 12 | es |
dc.publication.issue | 5 | es |
dc.publication.initialPage | 1123 | es |
dc.contributor.funder | Junta de Andalucía | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (MICINN). España | es |
dc.contributor.funder | Universidad de Sevilla | es |