Artículo
Tear Film Stabilization and Symptom Improvement in Dry Eye Disease: The Role of Hyaluronic Acid and Trehalose Eyedrops versus Carmellose Sodium
Autor/es | Sánchez González, José María
Silva Viguera, María del Carmen Sánchez González, María del Carmen Capote Puente, Raúl Hita Cantalejo, María Concepción de Ballesteros Sánchez, Antonio Ballesteros Durán, Lydia García Romera, Marta de la Concepción Gutiérrez Sánchez, Estanislao |
Departamento | Universidad de Sevilla. Departamento de Física de la Materia Condensada Universidad de Sevilla. Departamento de Cirugía |
Fecha de publicación | 2023-10-20 |
Fecha de depósito | 2023-11-20 |
Publicado en |
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Resumen | This study evaluated the effectiveness of hyaluronic acid and trehalose (HA/trehalose) eyedrops in managing dry eye disease (DED) symptoms by measuring tear stability and administering a DED questionnaire. Sixty patients ... This study evaluated the effectiveness of hyaluronic acid and trehalose (HA/trehalose) eyedrops in managing dry eye disease (DED) symptoms by measuring tear stability and administering a DED questionnaire. Sixty patients were treated with either HA/trehalose eyedrops (Tear A) or carmellose sodium eyedrops (Tear B) as controls. The tear breakup time (TBUT) and non-invasive breakup time (NIBUT) were monitored, and patients completed the standard patient evaluation of eye dryness (SPEED) questionnaire. After two months of twice-daily applications, patients treated with the HA/trehalose eyedrops demonstrated significant improvements in the NIBUT (12.98 ± 3.22 s) and TBUT (12.95 ± 2.98 s), indicating increased tear stability. Moreover, they reported lower dry eye sensation (6.70 ± 4.94 SPEED score points), suggesting a reduction in DED symptoms. These findings underscore the efficacy of HA/trehalose eyedrops in improving both the objective and subjective signs of DED, with twice-daily application enhancing ocular surface conditions and reducing patient-reported symptoms. © 2023 by the authors. |
Cita | Sánchez González, J.M., Silva Viguera, M.d.C., Sánchez González, M.d.C., Capote Puente, R., Hita Cantalejo, M.C.d., Ballesteros Sánchez, A.,...,Gutiérrez Sánchez, E. (2023). Tear Film Stabilization and Symptom Improvement in Dry Eye Disease: The Role of Hyaluronic Acid and Trehalose Eyedrops versus Carmellose Sodium. Journal of Clinical Medicine, 12 (20), 6647. https://doi.org/10.3390/jcm12206647. |
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