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dc.creatorMartínez Rodríguez, Saraes
dc.creatorOlmo Fernández, Albertoes
dc.creatorMartín Fernández, Danieles
dc.creatorMartín Garrido, Isabeles
dc.date.accessioned2023-10-10T08:40:23Z
dc.date.available2023-10-10T08:40:23Z
dc.date.issued2023-09-28
dc.identifier.citationMartínez Rodríguez, S., Olmo Fernández, A., Martín Fernández, D. y Martín Garrido, I. (2023). Bioimpedance spectroscopy characterization of Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) peripheral blood mononuclear cells. BIOMEDICAL LETTTERS, 9 (2), 121-128. https://doi.org/10.47262/bl/9.2.20230220.
dc.identifier.issn0961-088Xes
dc.identifier.issn2410-955Xes
dc.identifier.urihttps://hdl.handle.net/11441/149595
dc.description.abstractMyalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disabling and chronic disease, importantly related to the current COVID-19 pandemic. Currently, there are no specific laboratory tests to directly diagnose ME/CFS. In this work, the use of impedance spectroscopy is studied as a potential technique for the diagnosis of ME/CFS. A specific device for the electrical characterization of peripheral blood mononuclear cells was designed and implemented. Impedance spectroscopy measurements in the range from 1 Hz to 500 MHz were carried out after the osmotic stress of the samples with sodium chloride solution at 1M concentration. The evolution in time after the osmotic stress at two specific frequencies (1.36 kHz and 154 kHz) was analyzed. The device showed its sensitivity to the presence of cells and the evolution of the osmotic processes. Higher values of impedance (around 15% for both the real and imaginary part) were measured at 1.36 kHz in ME/CFS patients compared to control samples. No significant difference was found between patient samples and control samples at 154 kHz. Results help to further understand the diagnosis of ME/CFS patients and the relation of their blood samples with bioimpedance measurements.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.language.isoenges
dc.publisherThe Science Publisherses
dc.relation.ispartofBIOMEDICAL LETTTERS, 9 (2), 121-128.
dc.rightsAtribución-NoComercial 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectImpedance spectroscopyes
dc.subjectMyalgic Encephalomyelitises
dc.subjectChronic Fatigue Syndromees
dc.subjectMononuclear cellses
dc.subjectDiagnostic devicees
dc.subjectOsmotic stresses
dc.titleBioimpedance spectroscopy characterization of Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS) peripheral blood mononuclear cellses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Biología Celulares
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Tecnología Electrónica
dc.relation.publisherversionhttps://doi.org/10.47262/bl/9.2.20230220es
dc.identifier.doi10.47262/bl/9.2.20230220es
dc.journaltitleBIOMEDICAL LETTTERSes
dc.publication.volumen9es
dc.publication.issue2es
dc.publication.initialPage121es
dc.publication.endPage128es

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