dc.creator | Benítez Temiño, Beatriz | es |
dc.creator | García Hernández, Rosendo Miguel | es |
dc.creator | Rodríguez de la Cruz, Rosa María | es |
dc.creator | Pastor Loro, Ángel Manuel | es |
dc.date.accessioned | 2023-09-29T13:52:40Z | |
dc.date.available | 2023-09-29T13:52:40Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Benítez Temiño, B., García Hernández, R.M., Rodríguez de la Cruz, R.M. y Pastor Loro, Á.M. (2023). BDNF Influence on Adult Terminal Axon Sprouting after Partial Deafferentation. International Journal of Molecular Sciences, 24 (13), 10660. https://doi.org/10.3390/ijms241310660. | |
dc.identifier.issn | 1661-6596 | es |
dc.identifier.issn | 1422-0067 | es |
dc.identifier.uri | https://hdl.handle.net/11441/149232 | |
dc.description.abstract | BDNF is a neurotrophin family member implicated in many different neuronal functions, from neuronal survival during development to synaptic plasticity associated with processes of learning and memory. Its presence in the oculomotor system has previously been demonstrated, as it regulates afferent composition of extraocular motoneurons and their firing pattern. Moreover, BDNF expression increases after extraocular motoneuron partial deafferentation, in parallel with terminal axon sprouting from the remaining axons. To elucidate whether BDNF could play an active role in this process, we performed partial deafferentation of the medial rectus motoneurons through transection of one of the two main afferents, that is, the ascending tract of Deiters, and injected BDNF into the motoneuron target muscle, the medial rectus. Furthermore, to check whether BDNF could stimulate axon sprouting without lesions, we performed the same experiment without any lesions. Axon terminal sprouting was assessed by calretinin immunostaining, which specifically labels the remaining afferent system on medial rectus motoneurons, the abducens internuclear neurons. The results presented herein show that exogenous BDNF stimulated terminal axon growth, allowing the total recovery of synaptic coverage around the motoneuron somata. Moreover, calretinin staining in the neuropil exceeded that present in the control situation. Thus, BDNF could also stimulate axonal sprouting in the neuropil of intact animals. These results point to an active role of BDNF in plastic adaptations that take place after partial deafferentation. | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación RYC2021-033058-I, PID2021-124300NB-I00 | es |
dc.description.sponsorship | Junta de Andalucía P20_00529 | es |
dc.format | application/pdf | es |
dc.format.extent | 14 p. | es |
dc.language.iso | eng | es |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es |
dc.relation.ispartof | International Journal of Molecular Sciences, 24 (13), 10660. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Motoneuron | es |
dc.subject | Neurotrophin | es |
dc.subject | Oculomotor system | es |
dc.subject | Reactive synaptogenesis | es |
dc.title | BDNF Influence on Adult Terminal Axon Sprouting after Partial Deafferentation | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología | es |
dc.relation.projectID | RYC2021-033058-I | es |
dc.relation.projectID | PID2021-124300NB-I00 | es |
dc.relation.projectID | P20_00529 | es |
dc.relation.publisherversion | https://doi.org/10.3390/ijms241310660 | es |
dc.identifier.doi | 10.3390/ijms241310660 | es |
dc.journaltitle | International Journal of Molecular Sciences | es |
dc.publication.volumen | 24 | es |
dc.publication.issue | 13 | es |
dc.publication.initialPage | 10660 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | Junta de Andalucía | es |