dc.creator | Anastasiadi, Dafni | es |
dc.creator | Piferrer, Francesc | es |
dc.creator | Wellenreuther, Maren | es |
dc.creator | Benítez Burraco, Antonio | es |
dc.date.accessioned | 2023-07-31T07:03:08Z | |
dc.date.available | 2023-07-31T07:03:08Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Anastasiadi, D., Piferrer, F., Wellenreuther, M. y Benítez Burraco, A. (2022). Fish as Model Systems to Study Epigenetic Drivers in Human Self-Domestication and Neurodevelopmental Cognitive Disorders. Genes, 13, 987. https://doi.org/10.3390/genes13060987. | |
dc.identifier.issn | 2073-4425 | es |
dc.identifier.uri | https://hdl.handle.net/11441/148261 | |
dc.description.abstract | Modern humans exhibit phenotypic traits and molecular events shared with other domes ticates that are thought to be by-products of selection for reduced aggression. This is the human
self-domestication hypothesis. As one of the first types of responses to a novel environment, epi genetic changes may have also facilitated early self-domestication in humans. Here, we argue that
fish species, which have been recently domesticated, can provide model systems to study epigenetic
drivers in human self-domestication. To test this, we used in silico approaches to compare genes
with epigenetic changes in early domesticates of European sea bass with genes exhibiting methyla tion changes in anatomically modern humans (comparison 1), and neurodevelopmental cognitive
disorders considered to exhibit abnormal self-domestication traits, i.e., schizophrenia, Williams
syndrome, and autism spectrum disorders (comparison 2). Overlapping genes in comparison 1
were involved in processes like limb morphogenesis and phenotypes like abnormal jaw morphology
and hypopigmentation. Overlapping genes in comparison 2 affected paralogue genes involved in
processes such as neural crest differentiation and ectoderm differentiation. These findings pave the
way for future studies using fish species as models to investigate epigenetic changes as drivers of
human self-domestication and as triggers of cognitive disorders. | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación PID2020-114516GB-I00 | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación PID2019-108888RB-I00 | es |
dc.format | application/pdf | es |
dc.format.extent | 20 p. | es |
dc.language.iso | eng | es |
dc.relation.ispartof | Genes, 13, 987. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | domestication | es |
dc.subject | epigenetics | es |
dc.subject | vertebrates | es |
dc.subject | cognitive disorders | es |
dc.subject | human evolution | es |
dc.subject | DNA methylation | es |
dc.subject | domestication syndrome | es |
dc.subject | self-domestication | es |
dc.subject | neural crest | es |
dc.subject | fish | es |
dc.title | Fish as Model Systems to Study Epigenetic Drivers in Human Self-Domestication and Neurodevelopmental Cognitive Disorders | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Lengua Española, Lingüística y Teoría de la Literatura | es |
dc.relation.projectID | PID2020-114516GB-I00 | es |
dc.relation.projectID | PID2019-108888RB-I00 | es |
dc.relation.publisherversion | https://doi.org/10.3390/genes13060987 | es |
dc.identifier.doi | 10.3390/genes13060987 | es |
dc.journaltitle | Genes | es |
dc.publication.issue | 13 | es |
dc.publication.initialPage | 987 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |