Artículo
Fish as Model Systems to Study Epigenetic Drivers in Human Self-Domestication and Neurodevelopmental Cognitive Disorders
Autor/es | Anastasiadi, Dafni
Piferrer, Francesc Wellenreuther, Maren Benítez Burraco, Antonio ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Departamento | Universidad de Sevilla. Departamento de Lengua Española, Lingüística y Teoría de la Literatura |
Fecha de publicación | 2022 |
Fecha de depósito | 2023-07-31 |
Publicado en |
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Resumen | Modern humans exhibit phenotypic traits and molecular events shared with other domes ticates that are thought to be by-products of selection for reduced aggression. This is the human
self-domestication hypothesis. As one ... Modern humans exhibit phenotypic traits and molecular events shared with other domes ticates that are thought to be by-products of selection for reduced aggression. This is the human self-domestication hypothesis. As one of the first types of responses to a novel environment, epi genetic changes may have also facilitated early self-domestication in humans. Here, we argue that fish species, which have been recently domesticated, can provide model systems to study epigenetic drivers in human self-domestication. To test this, we used in silico approaches to compare genes with epigenetic changes in early domesticates of European sea bass with genes exhibiting methyla tion changes in anatomically modern humans (comparison 1), and neurodevelopmental cognitive disorders considered to exhibit abnormal self-domestication traits, i.e., schizophrenia, Williams syndrome, and autism spectrum disorders (comparison 2). Overlapping genes in comparison 1 were involved in processes like limb morphogenesis and phenotypes like abnormal jaw morphology and hypopigmentation. Overlapping genes in comparison 2 affected paralogue genes involved in processes such as neural crest differentiation and ectoderm differentiation. These findings pave the way for future studies using fish species as models to investigate epigenetic changes as drivers of human self-domestication and as triggers of cognitive disorders. |
Agencias financiadoras | Ministerio de Ciencia e Innovación (MICIN). España |
Identificador del proyecto | PID2020-114516GB-I00
![]() PID2019-108888RB-I00 ![]() |
Cita | Anastasiadi, D., Piferrer, F., Wellenreuther, M. y Benítez Burraco, A. (2022). Fish as Model Systems to Study Epigenetic Drivers in Human Self-Domestication and Neurodevelopmental Cognitive Disorders. Genes, 13, 987. https://doi.org/10.3390/genes13060987. |
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genes-13-00987-v2.pdf | 2.023Mb | ![]() | Ver/ | |