dc.creator | Allsopp, Luke P. | es |
dc.creator | Bernal Guzmán, Patricia | es |
dc.date.accessioned | 2023-07-26T10:50:14Z | |
dc.date.available | 2023-07-26T10:50:14Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Allsopp, L.P. y Bernal Guzmán, P. (2023). Killing in the name of: T6SS structure and effector diversity. Microbiology, 169 (7), 001367. https://doi.org/10.1099/mic.0.001367. | |
dc.identifier.issn | 1350-0872 | es |
dc.identifier.issn | 1465-2080 | es |
dc.identifier.uri | https://hdl.handle.net/11441/148216 | |
dc.description.abstract | The life of bacteria is challenging, to endure bacteria employ a range of mechanisms to optimize their environment, including
deploying the type VI secretion system (T6SS). Acting as a bacterial crossbow, this system delivers effectors responsible for
subverting host cells, killing competitors and facilitating general secretion to access common goods. Due to its importance,
this lethal machine has been evolutionarily maintained, disseminated and specialized to fulfil these vital functions. In fact,
T6SS structural clusters are present in over 25% of Gram-negative bacteria, varying in number from one to six different
genetic clusters per organism. Since its discovery in 2006, research on the T6SS has rapidly progressed, yielding remarkable breakthroughs. The identification and characterization of novel components of the T6SS, combined with biochemical and
structural studies, have revealed fascinating mechanisms governing its assembly, loading, firing and disassembly processes.
Recent findings have also demonstrated the efficacy of this system against fungal and Gram-positive cells, expanding its scope.
Ongoing research continues to uncover an extensive and expanding repertoire of T6SS effectors, the genuine mediators of
T6SS function. These studies are shedding light on new aspects of the biology of prokaryotic and eukaryotic organisms. This
review provides a comprehensive overview of the T6SS, highlighting recent discoveries of its structure and the diversity of its
effectors. Additionally, it injects a personal perspective on avenues for future research, aiming to deepen our understanding of
this combative system. | es |
dc.description.sponsorship | Academy of Medical Sciences/the Wellcome Trust/the Government Department of Business, Energy and Industrial Strategy/the British Heart Foundation/Diabetes UK Springboard Award - SBF006\1161 | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación de España (MCIN), Agencia Estatal de Investigación (AEI) la Unión Europea (UE) - PID2021-123000OB-I00 y TED2021-130357B-I00 | es |
dc.format | application/pdf | es |
dc.format.extent | 22 p. | es |
dc.language.iso | eng | es |
dc.publisher | Microbiology Society | es |
dc.relation.ispartof | Microbiology, 169 (7), 001367. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Type VI secretion system | es |
dc.subject | T6SS | es |
dc.subject | antimicrobial effectors | es |
dc.subject | antieukaryotic effectors | es |
dc.subject | T6SS assembly | es |
dc.subject | membrane complex | es |
dc.subject | baseplate | es |
dc.subject | tail | es |
dc.subject | inner tube | es |
dc.subject | contractile sheath | es |
dc.title | Killing in the name of: T6SS structure and effector diversity | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Microbiología | es |
dc.relation.projectID | SBF006\1161 | es |
dc.relation.projectID | PID2021-123000OB-I00 | es |
dc.relation.projectID | TED2021-130357B-I00 | es |
dc.relation.publisherversion | https://doi.org/10.1099/mic.0.001367 | es |
dc.identifier.doi | 10.1099/mic.0.001367 | es |
dc.journaltitle | Microbiology | es |
dc.publication.volumen | 169 | es |
dc.publication.issue | 7 | es |
dc.publication.initialPage | 001367 | es |
dc.contributor.funder | Wellcome Trust. UK. | es |
dc.contributor.funder | Government Department of Business, Energy and Industrial Strategy. UK. | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | Agencia Estatal de Investigación. España | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |