Artículo
Oxidative stress: Normal pregnancy versus preeclampsia
Autor/es | Chiarello, Delia Indira
Abad, Cilia Rojas, Deliana Toledo, Fernando Vázquez Cueto, Carmen María Mate Barrero, Alfonso Sobrevia Luarte, Luis Marín, Reinaldo |
Departamento | Universidad de Sevilla. Departamento de Fisiología |
Fecha de publicación | 2020 |
Fecha de depósito | 2023-07-05 |
Publicado en |
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Resumen | The role of oxidative stress in the physiopathology of human pregnancy is of particular interest. Pregnancy is well-known to increase the oxidative stress, mainly produced by a normal systemic inflammatory response, which ... The role of oxidative stress in the physiopathology of human pregnancy is of particular interest. Pregnancy is well-known to increase the oxidative stress, mainly produced by a normal systemic inflammatory response, which results in high amounts of circulating reactive oxygen species (ROS) and reactive nitrogen species (RNS). Both ROS and RNS play an important role as secondary messengers in many intracellular signalling cascades. However, they can also exert critical effects on pathological processes involving the pregnant woman. ROS, RNS and antioxidants establish a balance that determines the oxidation status of animals and humans. This review focuses on the mechanism of oxidative stress in pregnancy as well as its involvement and consequences on the human pregnancy-specific clinical syndrome preeclampsia. |
Agencias financiadoras | Organización Mundial de la Salud Fondo Nacional de Ciencia Tecnología e Innovación (FONACIT) Agencia Española de Cooperación Internacional para el Desarrollo (AECID) Junta de Andalucía Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT). Chile |
Identificador del proyecto | H9/181/R427
F-2005000222 C/024225/09 D/031187/10 A1/036123/11 CTS-584 1150377 11150083 |
Cita | Chiarello, D.I., Abad, C., Rojas, D., Toledo, F., Vázquez Cueto, C.M., Mate Barrero, A.,...,Marín, R. (2020). Oxidative stress: Normal pregnancy versus preeclampsia. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1866 (2), 165354. https://doi.org/10.1016/j.bbadis.2018.12.005. |
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