Artículo
Effects of pulsed electromagnetic field therapy on fatigue, walking performance, depression, and quality of life in adults with multiple sclerosis: a randomized placebo-controlled trial
Autor/es | Granja-Domínguez, Anabel
Hochsprung, Anja Luque Moreno, Carlos Magni, Eleonora Escudero-Uribe, Shahid Izquierdo-Ayuso, Guillermo Heredia Rizo, Alberto Marcos |
Departamento | Universidad de Sevilla. Departamento de Fisioterapia Universidad de Sevilla. Departamento de Enfermería |
Fecha de publicación | 2022 |
Fecha de depósito | 2023-07-05 |
Publicado en |
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Resumen | Background: Multiple sclerosis has a great disability burden. Management of the disease is complex, and patients often seek new conservative approaches.
Objective: To investigate the effect of low-frequency pulsed ... Background: Multiple sclerosis has a great disability burden. Management of the disease is complex, and patients often seek new conservative approaches. Objective: To investigate the effect of low-frequency pulsed electromagnetic field (PEMF) therapy, compared to placebo, on the level of fatigue, walking performance, symptoms of depression, and quality of life (QOL) in patients with relapsing-remitting multiple sclerosis (RRMS). Methods: Forty-four adults with RRMS and minimal to significant disability were randomly assigned to a 4-week protocol using a PEMF or a placebo whole-body mat. The PEMF group were initially treated with 15Hz frequency, gradually increased to 30Hz (intensity between 25-35mT). The primary outcome was fatigue, assessed with the Fatigue Severity Scale (FSS) and the Modified Fatigue Impact Scale (MFIS). Secondary measures included walking function (GAITRite system and Timed 25-Foot Walk test), the Beck Depression Inventory-II, and the Multiple Sclerosis International Quality of Life Questionnaire. Data were collected at baseline, after intervention, and at 3-months post-intervention (follow-up). Results: There were no differences between groups for changes in fatigue symptoms from baseline to end of intervention (mean and 95% confidence interval FSS: -0.6, 95%CI: -1.3, 0.1; MFIS: -5.4, 95% CI: -15.1, 4.4) or at follow-up (FSS: -0.6, 95% CI: -1.4, 0.2; MFIS: -2.1, 95% CI: -10.9, 6.8). Similarly, both groups did not differ for any of the secondary outcomes at post-intervention or follow-up. Conclusions: Low-frequency PEMF therapy is no more effective than placebo to produce changes in fatigue, gait performance, severity of depression, and QOL in people with RRMS and minimal to significant disability. |
Cita | Granja-Domínguez, A., Hochsprung, A., Luque Moreno, C., Magni, E., Escudero-Uribe, S., Izquierdo-Ayuso, G. y Heredia Rizo, A.M. (2022). Effects of pulsed electromagnetic field therapy on fatigue, walking performance, depression, and quality of life in adults with multiple sclerosis: a randomized placebo-controlled trial. BRAZILIAN JOURNAL OF PHYSICAL THERAPY (1413-3555 / 1809-9246). https://doi.org/10.1016/j.bjpt.2022.100449. |
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