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dc.creatorCivantos, Anaes
dc.creatorMesa Restrepo, Andreaes
dc.creatorTorres Hernández, Yadires
dc.creatorShetty, Akshathes
dc.creatorCheng, Ming Kites
dc.creatorJaramillo-Correa, Camiloes
dc.creatorAditya, Teresaes
dc.creatorAllain, Jean Paules
dc.date.accessioned2023-06-28T10:29:41Z
dc.date.available2023-06-28T10:29:41Z
dc.date.issued2023-06
dc.identifier.issn1549-3296es
dc.identifier.issn1552-4965es
dc.identifier.urihttps://hdl.handle.net/11441/147536
dc.description.abstractStress shielding and osseointegration are two main challenges in bone regeneration, which have been targeted successfully by chemical and physical surface modification methods. Direct irradiation synthesis (DIS) is an energetic ion irradiation method that generates self-organized nanopatterns conformal to the surface of materials with complex geometries (e.g., pores on a material surface). This work exposes porous titanium samples to energetic argon ions generating nanopatterning between and inside pores. The unique porous architected titanium (Ti) structure is achieved by mixing Ti powder with given amounts of spacer NaCl particles (vol % equal to 30%, 40%, 50%, 60%, and 70%), compacted and sintered, and combined with DIS to generate a porous Ti with bone-like mechanical properties and hierarchical topography to enhance Ti osseointegration. The porosity percentages range between 25% and 30% using 30 vol % NaCl space-holder (SH) volume percentages to porosity rates of 63%–68% with SH volume of 70 vol % NaCl. Stable and reproducible nanopatterning on the flat surface between pores, inside pits, and along the internal pore walls are achieved, for the first time on any porous biomaterial. Nanoscale features were observed in the form of nanowalls and nanopeaks of lengths between 100 and 500 nm, thicknesses of 35-nm and heights between 100 and 200 nm on average. Bulk mechanical properties that mimic bone-like structures were observed along with increased wettability (by reducing contact values). Nano features were cell biocompatible and enhanced in vitro pre-osteoblast differentiation and mineralization. Higher alkaline phosphatase levels and increased calcium deposits were observed on irradiated 50 vol % NaCl samples at 7 and 14 days. After 24 h, nanopatterned porous samples decreased the number of attached macrophages and the formation of foreign body giant cells, confirming nanoscale tunability of M1–M2 immuno-activation with enhanced osseointegration.es
dc.formatapplication/pdfes
dc.format.extent16 p.es
dc.language.isoenges
dc.publisherWileyes
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectArgon irradiationes
dc.subjectConformal nanopatterninges
dc.subjectOsseointegrationes
dc.subjectOsteoblast differentiationes
dc.subjectPoroustitaniumes
dc.titleNanotextured porous titanium scaffolds by argon ion irradiation: Toward conformal nanopatterning and improved implant osseointegrationes
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transportees
dc.relation.projectIDPID2019-109371GB-I00es
dc.relation.projectIDUS-1259771es
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/full/10.1002/jbm.a.37582es
dc.identifier.doi10.1002/jbm.a.37582es
dc.contributor.groupUniversidad de Sevilla. TEP123: Metalurgia e Ingeniería de los Materialeses
dc.journaltitleJournal of Biomedical Materials Research Part Aes
dc.contributor.funderMinistry of Science and Innovation of Spain under the grant PID2019-109371GB-I00es
dc.contributor.funderJunta de Andalucía–FEDER (Spain) through the Project Ref. US-1259771es

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Except where otherwise noted, this item's license is described as: Attribution-NonCommercial-NoDerivatives 4.0 Internacional