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dc.creatorGeribaldi Doldán, Noeliaes
dc.creatorCarrascal Moreno, María Liviaes
dc.creatorPérez García, Patriciaes
dc.creatorOliva Montero, José Maríaes
dc.creatorPardillo Díaz, Ricardoes
dc.creatorDomínguez García, Samueles
dc.creatorBernal Utrera, Carloses
dc.creatorGómez Oliva, Ricardoes
dc.creatorMartínez Ortega, Sergioes
dc.creatorVerástegui, Cristinaes
dc.creatorNúñez Abades, Pedro Antonioes
dc.creatorCastro, Carmenes
dc.date.accessioned2023-06-06T18:15:23Z
dc.date.available2023-06-06T18:15:23Z
dc.date.issued2023
dc.identifier.citationGeribaldi Doldán, N., Carrascal Moreno, M.L., Pérez García, P., Oliva Montero, J.M., Pardillo Díaz, R., Domínguez García, S.,...,Castro, C. (2023). Migratory Response of Cells in Neurogenic Niches to Neuronal Death: The Onset of Harmonic Repair?. International Journal of Molecular Sciences, 24 (7). https://doi.org/10.3390/ijms24076587.
dc.identifier.issn1661-6596es
dc.identifier.issn1422-0067es
dc.identifier.urihttps://hdl.handle.net/11441/146987
dc.description.abstractHarmonic mechanisms orchestrate neurogenesis in the healthy brain within specific neurogenic niches, which generate neurons from neural stem cells as a homeostatic mechanism. These newly generated neurons integrate into existing neuronal circuits to participate in different brain tasks. Despite the mechanisms that protect the mammalian brain, this organ is susceptible to many different types of damage that result in the loss of neuronal tissue and therefore in alterations in the functionality of the affected regions. Nevertheless, the mammalian brain has developed mechanisms to respond to these injuries, potentiating its capacity to generate new neurons from neural stem cells and altering the homeostatic processes that occur in neurogenic niches. These alterations may lead to the generation of new neurons within the damaged brain regions. Notwithstanding, the activation of these repair mechanisms, regeneration of neuronal tissue within brain injuries does not naturally occur. In this review, we discuss how the different neurogenic niches respond to different types of brain injuries, focusing on the capacity of the progenitors generated in these niches to migrate to the injured regions and activate repair mechanisms. We conclude that the search for pharmacological drugs that stimulate the migration of newly generated neurons to brain injuries may result in the development of therapies to repair the damaged brain tissue.es
dc.description.sponsorshipMinisterio de Ciencia e Innovación RTI-2018-099908-B-C21, RTI-2018-099908-B-C22es
dc.description.sponsorshipJunta de Andalucía FEDER-UCA18-106647es
dc.description.sponsorshipFondo Europeo de Desarrollo Regional ITI-Cadiz-0042-2019es
dc.formatapplication/pdfes
dc.format.extent28 p.es
dc.language.isoenges
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)es
dc.relation.ispartofInternational Journal of Molecular Sciences, 24 (7).
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAlzheimer’s diseasees
dc.subjectBrain injury and strokees
dc.subjectEpilepsyes
dc.subjectHuntington’s diseasees
dc.subjectNeuroblast migrationes
dc.subjectNeurogenesises
dc.subjectParkinson’s diseasees
dc.titleMigratory Response of Cells in Neurogenic Niches to Neuronal Death: The Onset of Harmonic Repair?es
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Fisiologíaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Fisioterapiaes
dc.relation.projectIDRTI-2018-099908-B-C21es
dc.relation.projectIDRTI-2018-099908-B-C22es
dc.relation.projectIDFEDER-UCA18-106647es
dc.relation.projectIDITI-Cadiz-0042-2019es
dc.relation.publisherversionhttps://doi.org/10.3390/ijms24076587es
dc.identifier.doi10.3390/ijms24076587es
dc.journaltitleInternational Journal of Molecular Scienceses
dc.publication.volumen24es
dc.publication.issue7es
dc.contributor.funderMinisterio de Ciencia e Innovación (MICIN). Españaes
dc.contributor.funderJunta de Andalucíaes
dc.contributor.funderEuropean Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)es

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