dc.creator | Geribaldi Doldán, Noelia | es |
dc.creator | Carrascal Moreno, María Livia | es |
dc.creator | Pérez García, Patricia | es |
dc.creator | Oliva Montero, José María | es |
dc.creator | Pardillo Díaz, Ricardo | es |
dc.creator | Domínguez García, Samuel | es |
dc.creator | Bernal Utrera, Carlos | es |
dc.creator | Gómez Oliva, Ricardo | es |
dc.creator | Martínez Ortega, Sergio | es |
dc.creator | Verástegui, Cristina | es |
dc.creator | Núñez Abades, Pedro Antonio | es |
dc.creator | Castro, Carmen | es |
dc.date.accessioned | 2023-06-06T18:15:23Z | |
dc.date.available | 2023-06-06T18:15:23Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Geribaldi Doldán, N., Carrascal Moreno, M.L., Pérez García, P., Oliva Montero, J.M., Pardillo Díaz, R., Domínguez García, S.,...,Castro, C. (2023). Migratory Response of Cells in Neurogenic Niches to Neuronal Death: The Onset of Harmonic Repair?. International Journal of Molecular Sciences, 24 (7). https://doi.org/10.3390/ijms24076587. | |
dc.identifier.issn | 1661-6596 | es |
dc.identifier.issn | 1422-0067 | es |
dc.identifier.uri | https://hdl.handle.net/11441/146987 | |
dc.description.abstract | Harmonic mechanisms orchestrate neurogenesis in the healthy brain within specific neurogenic niches, which generate neurons from neural stem cells as a homeostatic mechanism. These newly generated neurons integrate into existing neuronal circuits to participate in different brain tasks. Despite the mechanisms that protect the mammalian brain, this organ is susceptible to many different types of damage that result in the loss of neuronal tissue and therefore in alterations in the functionality of the affected regions. Nevertheless, the mammalian brain has developed mechanisms to respond to these injuries, potentiating its capacity to generate new neurons from neural stem cells and altering the homeostatic processes that occur in neurogenic niches. These alterations may lead to the generation of new neurons within the damaged brain regions. Notwithstanding, the activation of these repair mechanisms, regeneration of neuronal tissue within brain injuries does not naturally occur. In this review, we discuss how the different neurogenic niches respond to different types of brain injuries, focusing on the capacity of the progenitors generated in these niches to migrate to the injured regions and activate repair mechanisms. We conclude that the search for pharmacological drugs that stimulate the migration of newly generated neurons to brain injuries may result in the development of therapies to repair the damaged brain tissue. | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación RTI-2018-099908-B-C21, RTI-2018-099908-B-C22 | es |
dc.description.sponsorship | Junta de Andalucía FEDER-UCA18-106647 | es |
dc.description.sponsorship | Fondo Europeo de Desarrollo Regional ITI-Cadiz-0042-2019 | es |
dc.format | application/pdf | es |
dc.format.extent | 28 p. | es |
dc.language.iso | eng | es |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es |
dc.relation.ispartof | International Journal of Molecular Sciences, 24 (7). | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Alzheimer’s disease | es |
dc.subject | Brain injury and stroke | es |
dc.subject | Epilepsy | es |
dc.subject | Huntington’s disease | es |
dc.subject | Neuroblast migration | es |
dc.subject | Neurogenesis | es |
dc.subject | Parkinson’s disease | es |
dc.title | Migratory Response of Cells in Neurogenic Niches to Neuronal Death: The Onset of Harmonic Repair? | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisioterapia | es |
dc.relation.projectID | RTI-2018-099908-B-C21 | es |
dc.relation.projectID | RTI-2018-099908-B-C22 | es |
dc.relation.projectID | FEDER-UCA18-106647 | es |
dc.relation.projectID | ITI-Cadiz-0042-2019 | es |
dc.relation.publisherversion | https://doi.org/10.3390/ijms24076587 | es |
dc.identifier.doi | 10.3390/ijms24076587 | es |
dc.journaltitle | International Journal of Molecular Sciences | es |
dc.publication.volumen | 24 | es |
dc.publication.issue | 7 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | Junta de Andalucía | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |