Artículo
Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium
Autor/es | van Velzen, Laura S.
Dauvermann, Maria R. Colic, Lejla Villa, Luca M. Savage, Hannah S. Toenders, Yara J. Crespo Facorro, Benedicto Schmaal, Lianne |
Departamento | Universidad de Sevilla. Departamento de Psiquiatría |
Fecha de publicación | 2022-09-07 |
Fecha de depósito | 2023-05-30 |
Publicado en |
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Resumen | Identifying brain alterations associated with suicidal thoughts and behaviors (STBs) in young people is critical to understanding their development and improving early intervention and prevention. The ENIGMA Suicidal ... Identifying brain alterations associated with suicidal thoughts and behaviors (STBs) in young people is critical to understanding their development and improving early intervention and prevention. The ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium analyzed neuroimaging data harmonized across sites to examine brain morphology associated with STBs in youth. We performed analyses in three separate stages, in samples ranging from most to least homogeneous in terms of suicide assessment instrument and mental disorder. First, in a sample of 577 young people with mood disorders, in which STBs were assessed with the Columbia Suicide Severity Rating Scale (C-SSRS). Second, in a sample of young people with mood disorders, in which STB were assessed using different instruments, MRI metrics were compared among healthy controls without STBs (HC; N = 519), clinical controls with a mood disorder but without STBs (CC; N = 246) and young people with current suicidal ideation (N = 223). In separate analyses, MRI metrics were compared among HCs (N = 253), CCs (N = 217), and suicide attempters (N = 64). Third, in a larger transdiagnostic sample with various assessment instruments (HC = 606; CC = 419; Ideation = 289; HC = 253; CC = 432; Attempt=91). In the homogeneous C-SSRS sample, surface area of the frontal pole was lower in young people with mood disorders and a history of actual suicide attempts (N = 163) than those without a lifetime suicide attempt (N = 323; FDR-p = 0.035, Cohen’s d = 0.34). No associations with suicidal ideation were found. When examining more heterogeneous samples, we did not observe significant associations. Lower frontal pole surface area may represent a vulnerability for a (non-interrupted and non-aborted) suicide attempt; however, more research is needed to understand the nature of its relationship to suicide risk. |
Agencias financiadoras | American Foundation for Suicide Prevention (AFSP) Australian National Health and Medical Research Council (NHMRC) Biotechnology Research Center Brain and Behavior Research Foundation CJ Martin Fellowship (NHMRC) Deborah E. Powell Center for Women's Health Seed Grant, University of Minnesota European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) /Fondo Social Europeo "Invertir en tu futuro" Famous Doctors Project of Yunnan Province Plan For the Love of Travis Foundation Fundacion Instituto de Investigacion Marques de Valdecilla Deutsche Forschungsgemeinschaft / German Research Foundation (DFG) Good Talk Instituto de Salud Carlos III Interdisziplinares Zentrum fur Klinische Forschung, UKJ International Bipolar Foundation Ministerio italiano de Salud J. Jacobson Fund. Janette Mary O'Neil Research Fellowship Keith Pettigrew Family Bequest Klingenstein Third Generation Foundation Lansdowne Foundation Medical Faculty Munster, Innovative Medizinische Forschung Medical Leader Foundation of Yunnan Province Minnesota Medical Foundation MQ Brighter Futures MQ Brighter Futures Award National Alliance for Research on Schizophrenia and Depression National Center for Advancing Translational Sciences (CTSI), National Institutes of Health National Center for Complementary and Integrative Health (NCCIH) National Institute of Mental Health (NIMH) NHMRC Career Development Fellowships NIAAA Program "Investissements d'avenir" Ray and Dagmar Dolby Family Fund. Social Safety and Resilience program of Leiden University Stanford Center for Cognitive and Neurobiological Imaging Stanford Maternal Child Health Research Institute U.S. National Institute of Mental Health UCSF Research Evaluation and Allocation Committee (REAC) University of Minnesota Women's Health Research at Yale |
Identificador del proyecto | R61MH111929RC1MH088366
R01MH070902 R01MH069747 R37MH101495 SRG-1-141-18 GNT1042580 1064643 1024570 1037196 1177991 1066177 P41 RR008079 1161356 NE2254/1-2 NE2254/3-1 NE2254/4-1 YNWR-MY-2018-041 NCT0235832; NCT02534363 FOR2107-DA1151/5-1 DA1151/5-2 HA7070/2-2 HA7070/3 HA7070/4 FOR2107-JA 1890/7-1 JA 1890/7-2 FOR2107-KI588/14-1 FOR2107-KI588/14-2 PI14/00639 PI14/00918 PI17/01056 RC17-18-19-20-21/A IMF KO 1218 06 L2019011 MQBFC/2 UCSF-CTSI UL1TR001872 R21AT009173 R61AT009864 R01MH085734 K23MH090421 K01MH106805 K01MH117442 R01-MH103291 1140764 1124472 1061757 K01AA027573 R21AA027884 ANR-10-IAIHU-06 R01MH117601 |
Cita | van Velzen, L.S., Dauvermann, M.R., Colic, L., Villa, L.M., Savage, H.S., Toenders, Y.J.,...,Schmaal, L. (2022). Structural brain alterations associated with suicidal thoughts and behaviors in young people: results from 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium. Molecular Psychiatry, 27 (11), 4550-4560. https://doi.org/10.1038/s41380-022-01734-0. |
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