Artículo
Pattern of long-term weight and metabolic changes after a first episode of psychosis Results from a 10-year prospective follow-up of the PAFIP program for early intervention in psychosis cohort
Autor/es | Vázquez-Bourgon, Javier
Gómez-Revuelta, Marcos Mayoral-van Son, Jaqueline Labad, Javier Ortiz García de la Foz, Víctor Setién Suero, Esther Ayesa-Arriola, Rosa Tordesillas-Gutiérrez, Diana Juncal-Ruiz, María Crespo Facorro, Benedicto |
Departamento | Universidad de Sevilla. Departamento de Psiquiatría |
Fecha de publicación | 2022-08-16 |
Fecha de depósito | 2023-05-30 |
Publicado en |
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Resumen | Background
People with psychosis are at higher risk of cardiovascular events, partly explained by a higher predisposition to gain weight. This has been observed in studies on individuals with a first-episode psychosis ... Background People with psychosis are at higher risk of cardiovascular events, partly explained by a higher predisposition to gain weight. This has been observed in studies on individuals with a first-episode psychosis (FEP) at short and long term (mainly up to 1 year) and transversally at longer term in people with chronic schizophrenia. However, there is scarcity of data regarding longer-term (above 3-year follow-up) weight progression in FEP from longitudinal studies. The aim of this study is to evaluate the longer-term (10 years) progression of weight changes and related metabolic disturbances in people with FEP. Methods Two hundred and nine people with FEP and 57 healthy participants (controls) were evaluated at study entry and prospectively at 10-year follow-up. Anthropometric, clinical, and sociodemographic data were collected. Results People with FEP presented a significant and rapid increase in mean body weight during the first year of treatment, followed by less pronounced but sustained weight gain over the study period (Δ15.2 kg; SD 12.3 kg). This early increment in weight predicted longer-term changes, which were significantly greater than in healthy controls (Δ2.9 kg; SD 7.3 kg). Weight gain correlated with alterations in lipid and glycemic variables, leading to clinical repercussion such as increments in the rates of obesity and metabolic disturbances. Sex differences were observed, with women presenting higher increments in body mass index than men. Conclusions This study confirms that the first year after initiating antipsychotic treatment is the critical one for weight gain in psychosis. Besides, it provides evidence that weight gain keep progressing even in the longer term (10 years), causing relevant metabolic disturbances. |
Agencias financiadoras | Instituto de Investigacion Sanitaria Valdecilla Instituto de Salud Carlos III |
Identificador del proyecto | INT/A21/10
INT/A20/04 NEXTVAL17/24 PI020499 PI050427 PI060507 |
Cita | Vázquez-Bourgon, J., Gómez-Revuelta, M., Mayoral-van Son, J., Labad, J., Ortiz García de la Foz, V., Setién Suero, E.,...,Crespo Facorro, B. (2022). Pattern of long-term weight and metabolic changes after a first episode of psychosis Results from a 10-year prospective follow-up of the PAFIP program for early intervention in psychosis cohort. European Psychiatry, 65 (1), e48. https://doi.org/10.1192/j.eurpsy.2022.2308. |
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