dc.creator | Montserrat de la Paz, Sergio | es |
dc.creator | Rodríguez Martín, Noelia María | es |
dc.creator | Villanueva, Alberto | es |
dc.creator | Pedroche, J. | es |
dc.creator | Cruz Chamorro, Iván | es |
dc.creator | Millán, Francisco | es |
dc.creator | Millán-Linares, María del Carmen | es |
dc.date.accessioned | 2023-05-19T07:53:52Z | |
dc.date.available | 2023-05-19T07:53:52Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Montserrat de la Paz, S., Rodríguez Martín, N.M., Villanueva, A., Pedroche, J., Cruz Chamorro, I., Millán, F. y Millán-Linares, M.d.C. (2020). Evaluation of anti-inflammatory and atheroprotective properties of wheat gluten protein hydrolysates in primary human monocytes. Foods, 9 (7), 1-16. https://doi.org/10.3390/foods9070854. | |
dc.identifier.issn | 2304-8158 | es |
dc.identifier.uri | https://hdl.handle.net/11441/146394 | |
dc.description.abstract | Bioactive protein hydrolysates have been identified in several sources as possible agents in the prevention and treatment of many diseases. A wheat gluten (WG) concentrate was hydrolyzed by Alcalase under specific conditions. The resulting hydrolysates were evaluated by in vitro cell-free experiments leading to the identification of one bioactive WG protein hydrolysate (WGPH), which was used at 50 and 100 μg/mL on primary human monocytes. Reactive oxygen species (ROS) and nitrite levels and RT-qPCR and ELISA techniques were used to analyze the functional activity of WGPH. Our results showed that WGPH hydrolyzed in 45 min (WGPH45A) down-regulated gene expression of Interleukin (IL)-1β, IL-6, IL-17, and Interferon gamma (IFNγ) and reduced cytokine release in lipopolysaccharide (LPS)-stimulated monocytes. In addition, WGPH45A down-regulated gene-related to atherosclerotic onset. Our results suggest that WGPH45A has a potent anti-inflammatory and atheroprotective properties, reducing the expression of gene-related inflammation and atherosclerosis that could be instrumental in maintaining cardiovascular homeostasis. | es |
dc.description.sponsorship | Ministerio de Ciencia, Innovación y Universidades Grant CYTED-2019 119RT0567 | es |
dc.format | application/pdf | es |
dc.format.extent | 16 | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Foods, 9 (7), 1-16. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Wheat gluten | es |
dc.subject | Protein hydrolysates | es |
dc.subject | Atherosclerosis | es |
dc.subject | Monocytes | es |
dc.subject | Celiac disease | es |
dc.title | Evaluation of anti-inflammatory and atheroprotective properties of wheat gluten protein hydrolysates in primary human monocytes | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.identifier.doi | 10.3390/foods9070854 | es |
dc.contributor.group | Universidad de Sevilla. CTS1074: Inmunonutrición e Inmunometabolismo | es |
dc.contributor.group | Universidad de Sevilla. CTS160: Neuroinmunoendocrinología Molecular | es |
dc.journaltitle | Foods | es |
dc.publication.volumen | 9 | es |
dc.publication.issue | 7 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 16 | es |