dc.creator | Sánchez Molina, Sara | es |
dc.creator | Figuerola Bou, Elisabet | es |
dc.creator | Blanco, Enrique | es |
dc.creator | Sánchez Jiménez, María | es |
dc.creator | Táboas, Pablo | es |
dc.creator | Gómez, Soledad | es |
dc.creator | Álava Casado, Enrique de | es |
dc.date.accessioned | 2023-05-17T09:20:14Z | |
dc.date.available | 2023-05-17T09:20:14Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Sánchez Molina, S., Figuerola Bou, E., Blanco, E., Sánchez Jiménez, M., Táboas, P., Gómez, S. y Álava Casado, E.d. (2020). RING1B recruits EWSR1-FLI1 and cooperates in the remodeling of chromatin necessary for Ewing sarcoma tumorigenesis. Science Advances, 6 (43), 1-16. https://doi.org/10.1126/sciadv.aba3058. | |
dc.identifier.issn | 2375-2548 | es |
dc.identifier.uri | https://hdl.handle.net/11441/146183 | |
dc.description.abstract | Ewing sarcoma (EwS) is an aggressive tumor that affects adolescents and young adults. EwS is defined by a chromosomal translocation, EWSR1-FLI1 being the most common, that causes genome reprogramming through remodeling of enhancers. Here, we describe an unexpected function of RING1B, which is highly expressed in EwS. While retaining its repressive activity at Polycomb developmental regulated genes, RING1B colocalizes with EWSR1-FLI1 at active enhancers. We demonstrate that RING1B is necessary for the expression of key EWSR1-FLI1 targets by facilitating oncogene recruitment to their enhancers. Knockdown of RING1B impairs growth of tumor xenografts and expression of genes regulated by EWSR1-FLI1 bound enhancers. Pharmacological inhibition of AURKB with AZD1152 increases H2Aub levels causing down-regulation of RING1B/EWSR1-FLI1 common targets. Our findings demonstrate that RING1B is a critical modulator of EWSR1-FLI1–induced chromatin remodeling, and its inhibition is a potential therapeutic strategy for the treatment of these tumors. | es |
dc.description.sponsorship | Asociación Española Contra el Cáncer (AECC) GCB13131578 | es |
dc.description.sponsorship | Asociación Pablo Ugarte (APU) | es |
dc.description.sponsorship | Instituto de Salud Carlos III PI16/00245 | es |
dc.description.sponsorship | Ministerio de Economía, Industria y Competitividad (MEIC) BFU2016-75008-P | es |
dc.description.sponsorship | Fundación Vencer el Cáncer (VEC) | es |
dc.format | application/pdf | es |
dc.format.extent | 16 | es |
dc.language.iso | eng | es |
dc.publisher | American Association for the Advancement of Science | es |
dc.relation.ispartof | Science Advances, 6 (43), 1-16. | |
dc.rights | Atribución-NoComercial 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | Ewing sarcoma (EwS) | es |
dc.subject | Tumorigenesis | es |
dc.subject | Tumors | es |
dc.subject | Adolescents | es |
dc.subject | Chromosomal translocation | es |
dc.subject | Genome | es |
dc.subject | Young Adults | es |
dc.subject | Pharmacological inhibition | es |
dc.title | RING1B recruits EWSR1-FLI1 and cooperates in the remodeling of chromatin necessary for Ewing sarcoma tumorigenesis | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Citología e Histología Normal y Patológica | es |
dc.identifier.doi | 10.1126/sciadv.aba3058 | es |
dc.contributor.group | Universidad de Sevilla. CTS1035: Patología Molecular del Cáncer Sólido | es |
dc.journaltitle | Science Advances | es |
dc.publication.volumen | 6 | es |
dc.publication.issue | 43 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 16 | es |