dc.creator | Callejas, Juan Antonio | es |
dc.creator | Brizuela, Aritza | es |
dc.creator | Ríos Carrasco, Blanca | es |
dc.creator | Gil, Javier | es |
dc.date.accessioned | 2023-05-04T13:19:25Z | |
dc.date.available | 2023-05-04T13:19:25Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Callejas, J.A., Brizuela, A., Ríos Carrasco, B. y Gil, J. (2022). The Characterization of Titanium Particles Released from Bone-Level Titanium Dental Implants: Effect of the Size of Particles on the Ion Release and Cytotoxicity Behaviour. Materials, 15 (10), 3636. https://doi.org/10.3390/ma15103636. | |
dc.identifier.issn | 1996-1944 | es |
dc.identifier.uri | https://hdl.handle.net/11441/145415 | |
dc.description.abstract | Many studies are being carried out on the particles released during the implantoplasty
process in the machining of dental implants to remove bacterial biofilms. However, there are no
studies on the release of particles produced by the insertion of bone-level dental implants due to
the high compressive frictional loads between the rough titanium implant and the bone tissue. This
paper aims to characterize the released particles and determine the release of titanium ions into the
physiological environment and their cytocompatibility. For this purpose, 90 dental implants with a
neck diameter of 4 mm and a torque of 22 Ncm were placed in 7 fresh cow ribs. The placement was
carried out according to the established protocols. The implants had a roughness Ra of 1.92 µm. The
arrangement of the particles in the bone tissue was studied by micro-CT, and no particle clusters were
observed. The different granulometries of 5, 15, and 30 µm were obtained; the specific surface area
was determined by laser diffraction; the topography was determined by scanning electron microcopy;
and the particles were chemically analysed by X-ray energy microanalysis. The residual stresses of
the particles were obtained by X-ray diffraction using the Bragg-Bentano configuration. The release
of titanium ions to the physiological medium was performed using ICP-MS at 1, 3, 7, 14, and 21 days.
The cytocompatibility of the particles with HFF-1 fibroblast and SAOS-2 osteoblast cultures was
characterized. The results showed that the lowest specific surface area (0.2109 m2/g) corresponds
to the particles larger than 30 µm being higher than 0.4969 and 0.4802 m2/g of those that are 5 and
15 µm, respectively, observing in all cases that the particles have irregular morphologies without
contamination of the drills used in the surgery. The highest residual stresses were found for the
small particles, −395 MPa for the 5 µm particles, and −369 for the 15 µm particles, and the lowest
residual stresses were found for the 30 µm particles with values of −267 MPa. In all cases, the residual
stresses were compressive. The lowest ion release was for the 30 µm samples, as they have the lowest
specific surface area. Cytocompatibility studies showed that the particles are cytocompatible, but it
is the smallest ones that are lower and very close to the 70% survival limit in both fibroblasts and
osteoblasts. | es |
dc.format | application/pdf | es |
dc.format.extent | 15 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Materials, 15 (10), 3636. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Titanium debris | es |
dc.subject | Bone level implants | es |
dc.subject | Friction forces | es |
dc.subject | Chemical degradation | es |
dc.subject | Cytotoxicity | es |
dc.title | The Characterization of Titanium Particles Released from Bone-Level Titanium Dental Implants: Effect of the Size of Particles on the Ion Release and Cytotoxicity Behaviour | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Estomatología | es |
dc.relation.publisherversion | https://www.mdpi.com/1996-1944/15/10/3636 | es |
dc.identifier.doi | 10.3390/ma15103636 | es |
dc.journaltitle | Materials | es |
dc.publication.volumen | 15 | es |
dc.publication.issue | 10 | es |
dc.publication.initialPage | 3636 | es |