dc.creator | Gopi, Janani | es |
dc.creator | Marotta, Francesco | es |
dc.creator | Sriramulu, Sushmitha | es |
dc.creator | Banerjee, Antara | es |
dc.creator | Kanna, N.R. Rajesh | es |
dc.creator | Palani, Vignesh | es |
dc.creator | Ayala Gómez, Antonio | es |
dc.creator | He, Fang | es |
dc.creator | Vijayashree, R. | es |
dc.creator | Pathak, Surajit | es |
dc.date.accessioned | 2023-04-10T16:54:36Z | |
dc.date.available | 2023-04-10T16:54:36Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Gopi, J., Marotta, F., Sriramulu, S., Banerjee, A., Kanna, N.R.R., Palani, V.,...,Pathak, S. (2022). Anti-inflammatory effect of Phytomarine R-L compound against lipopolysaccharide- induced pulmonary injury in BALB/c mice. Functional Foods in Health and Disease, 12 (11), 666-679. https://doi.org/10.31989/ffhd.v12i11.1014. | |
dc.identifier.issn | 2378-7007 | es |
dc.identifier.issn | 2160-3855 | es |
dc.identifier.uri | https://hdl.handle.net/11441/144100 | |
dc.description.abstract | Background: This study deals with the induction of lipopolysaccharide induced inflammation in animal model and
treating this condition using phytomarine R-L compound (Bloomin’Age, Science of Living, Milan Italy) that is known to
possess the anti-inflammatory properties and eventually determine their characteristics through the in-vivo
experimentation.
Objective of the study: The present study was subjected to test the therapeutic anti-inflammatory/anti-oxidative and
regenerative property of this phytomarine (SBF-LF) in an LPS-induced lung injury in mice models. Methods: Mice received an intra-nasal administration of LPS at a concentration of 1 mg/ml weekly
for four consecutive weeks followed by the oral administration of R-L compound at a concentration of 50 mg/kg body
weight intermittently. Broncho-alveolar lavage fluids (BALF) as well as the lung tissues were periodically collected from the control and experimental groups for histological examination. Likewise, the lung tissue homogenate obtained from
induction and treatment groups was assayed for myeloperoxidase (MPO) assay, superoxide dismutase (SOD) activity
and elastase assay.
Results: The results illustrated that LPS- induced mice group demonstrated an increased inflammatory cell infiltration
causing an acute and persisting neutrophilic accumulation in the lung parenchyma with alveolar congestion.
Furthermore, the influx of macrophages, lymphocytes as well as inflammatory mediators was observed during the
BALF analysis. The treatment with R-L compound resulted in a significant decline in the permeation of inflammatory
cells as observed by lung histology and BALF analysis.
Conclusion: Thus, the exploitation of R-L compound with the experimental groups along with other assay methods
confirmed its robust anti-inflammatory and antioxidant properties and suggested epithelial regenerative capacity.
Further analyzing the efficacy of the R-L compound might help understanding its potential as a therapeutic option in
clinical settings. | es |
dc.format | application/pdf | es |
dc.format.extent | 14 p. | es |
dc.language.iso | eng | es |
dc.publisher | Functional Food Center Inc. | es |
dc.relation.ispartof | Functional Foods in Health and Disease, 12 (11), 666-679. | |
dc.rights | Atribución-NoComercial 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | Lungs | es |
dc.subject | BALB/c mice | es |
dc.subject | Lipopolysaccharide | es |
dc.subject | Anti-inflammatory | es |
dc.subject | R-L compound | es |
dc.title | Anti-inflammatory effect of Phytomarine R-L compound against lipopolysaccharide- induced pulmonary injury in BALB/c mice | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular | es |
dc.relation.publisherversion | https://doi.org/10.31989/ffhd.v12i11.1014 | es |
dc.identifier.doi | 10.31989/ffhd.v12i11.1014 | es |
dc.journaltitle | Functional Foods in Health and Disease | es |
dc.publication.volumen | 12 | es |
dc.publication.issue | 11 | es |
dc.publication.initialPage | 666 | es |
dc.publication.endPage | 679 | es |