dc.creator | Xiang, Zhenting | es |
dc.creator | Koo, Hyun | es |
dc.creator | Chen, Qianming | es |
dc.creator | Zhou, Xuedong | es |
dc.creator | Liu, Yuan | es |
dc.creator | Simón-Soro, Aúrea | es |
dc.date.accessioned | 2023-02-09T13:31:04Z | |
dc.date.available | 2023-02-09T13:31:04Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Xiang, Z., Koo, H., Chen, Q., Zhou, X., Liu, Y. y Simón-Soro, A. (2021). Potential implications of SARS-CoV-2 oral infection in the host microbiota. Journal of Oral Microbiology, 13 (1), 1853451. https://doi.org/10.1080/20002297.2020.1853451. | |
dc.identifier.issn | 2000-2297 | es |
dc.identifier.uri | https://hdl.handle.net/11441/142591 | |
dc.description.abstract | The oral cavity, as the entry point to the body, may play a critical role in the pathogenesis of SARS-CoV-2 infection that has caused a global outbreak of the coronavirus disease 2019 (COVID-19). Available data indicate that the oral cavity may be an active site of infection and an important reservoir of SARS-CoV-2. Considering that the oral surfaces are colonized by a diverse microbial community, it is likely that viruses have interactions with the host microbiota. Patients infected by SARS-CoV-2 may have alterations in the oral and gut micro-biota, while oral species have been found in the lung of COVID-19 patients. Furthermore, interactions between the oral, lung, and gut microbiomes appear to occur dynamically whereby a dysbiotic oral microbial community could influence respiratory and gastrointest-inal diseases. However, it is unclear whether SARS-CoV-2 infection can alter the local home-ostasis of the resident microbiota, actively cause dysbiosis, or influence cross-body sites interactions. Here, we provide a conceptual framework on the potential impact of SARS- CoV-2 oral infection on the local and distant microbiomes across the respiratory and gastro-intestinal tracts (‘oral-tract axes’), which remains largely unexplored. Studies in this area could further elucidate the pathogenic mechanism of SARS-CoV-2 and the course of infection as well as the clinical symptoms of COVID-19 across different sites in the human host. | es |
dc.format | application/pdf | es |
dc.format.extent | 6 p. | es |
dc.language.iso | eng | es |
dc.relation.ispartof | Journal of Oral Microbiology, 13 (1), 1853451. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Severe acute respiratory syndrome coronavirus 2 | es |
dc.subject | Angiotensin-converting enzyme 2 (ACE2) | es |
dc.subject | Oral-gut axis | es |
dc.subject | Oral-lung axis | es |
dc.subject | Microbiota | es |
dc.title | Potential implications of SARS-CoV-2 oral infection in the host microbiota | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Estomatología | es |
dc.relation.publisherversion | https://www.tandfonline.com/doi/full/10.1080/20002297.2020.1853451 | es |
dc.identifier.doi | 10.1080/20002297.2020.1853451 | es |
dc.journaltitle | Journal of Oral Microbiology | es |
dc.publication.volumen | 13 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 1853451 | es |