dc.creator | Galera Ruiz, Hugo | es |
dc.creator | Ríos, M. J. | es |
dc.creator | González Cámpora, R. | es |
dc.creator | Miguel Rodríguez, Manuel de | es |
dc.creator | Carmona, M. I. | es |
dc.creator | Moreno, A. M. | es |
dc.creator | Galera Davidson, Hugo | es |
dc.date.accessioned | 2023-02-08T14:26:31Z | |
dc.date.available | 2023-02-08T14:26:31Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Galera Ruiz, H., Ríos, M.J., González Cámpora, R., Miguel Rodríguez, M.d., Carmona, M.I., Moreno, A.M. y Galera Davidson, H. (2011). The cadherin–catenin complex in nasopharyngeal carcinoma. EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 268 (9), 1335-1341. https://doi.org/10.1007/s00405-010-1464-z. | |
dc.identifier.issn | 0937-4477 | es |
dc.identifier.issn | 1434-4726 | es |
dc.identifier.uri | https://hdl.handle.net/11441/142550 | |
dc.description.abstract | Abnormal Wnt signaling and impaired cell–cell
adhesion due to abnormal E-cadherin and b-catenin func tion have been implicated in many cancers, but have not
been fully explored in nasopharyngeal carcinoma. The aim
of this study was to analyze b-Catenin cellular location and
E-cadherin expression levels in nasopharyngeal carcinoma.
E-cadherin expression levels were also correlated with
clinical data and underlying pathology. b-Catenin and
E-cadherin expression were examined in 18 nasopharyn geal carcinoma and 7 non-tumoral inflammatory pharynx
tissues using immunohistochemical methods. Patient clin ical data were collected, and histological evaluation was
performed by hematoxylin/eosin staining. b-catenin was
detected in membrane and cytoplasm in all cases of naso pharyngeal carcinoma, regardless of histological type; in
non-tumoral tissues, however, b-catenin was observed only
in the membrane. As for E-cadherin expression levels,
strong staining was observed in most non-tumoral tissues,
but staining was only moderate in nasopharyngeal carci noma tissues. E-cadherin expression was associated with
b-catenin localization, study group, metastatic disease, and
patient outcomes. Reduced levels of E-cadherin protein
observed in nasopharyngeal carinoma may play an
important role in invasion and metastasis. Cytoplasmic
b-catenin in nasopharyngeal carcinoma may impair cell–
cell adhesion, promoting invasive behavior and a metastatic
tumor phenotype. | es |
dc.format | application/pdf | es |
dc.format.extent | 7 p. | es |
dc.language.iso | eng | es |
dc.publisher | SPRINGER | es |
dc.relation.ispartof | EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 268 (9), 1335-1341. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Nasopharyngeal carcinoma | es |
dc.subject | β-catenin | es |
dc.subject | E-cadherin | es |
dc.subject | Wnt signaling | es |
dc.title | The cadherin–catenin complex in nasopharyngeal carcinoma | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Cirugía | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica | es |
dc.relation.publisherversion | https://link.springer.com/article/10.1007/s00405-010-1464-z | es |
dc.identifier.doi | 10.1007/s00405-010-1464-z | es |
dc.contributor.group | Universidad de Sevilla. CTS949: Biopatología y estrés oxidativo. | es |
dc.journaltitle | EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | es |
dc.publication.volumen | 268 | es |
dc.publication.issue | 9 | es |
dc.publication.initialPage | 1335 | es |
dc.publication.endPage | 1341 | es |