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dc.creatorKoch, Michaeles
dc.creatorMiguel Rodríguez, Manuel dees
dc.creatorHofler, Heinzes
dc.creatorDiaz-Cano, Salvador J.es
dc.date.accessioned2023-02-07T15:30:19Z
dc.date.available2023-02-07T15:30:19Z
dc.date.issued2000-05
dc.identifier.citationKoch, M., Miguel Rodríguez, M.d., Hofler, H. y Diaz-Cano, S.J. (2000). Kinetic profiles of intraepithelial and invasive prostatic neoplasias: the key role of down-regulated apoptosis in tumor progression. Virchows Archiv, 536 (5), 413-420. https://doi.org/10.1007/s004280050468.
dc.identifier.issn1432-2307 ; 0945-6317es
dc.identifier.urihttps://hdl.handle.net/11441/142518
dc.description.abstractThe cell kinetic of prostatic intraepithelial neoplasia (PIN) is poorly understood. Herein we report the kinetic pattern of PIN, both not associated (primary) and associated (secondary) with coexistent invasive carcinoma (PCa). Surgical specimens collected in 20 cases of primary PIN, 20 of secondary PIN and 20 of PCa were studied by MIB-1 immunostaining, in situ end- labeling (ISEL) and DNA histogram analysis, and the cell density in each case was estimated using the formula N=(nπ/4)2. Fifty high-power fields (HPF), or the complete lesion if smaller, were screened in each lesion, and both mean and standard deviation were recorded. Statistical differences were studied by means of Fisher’s exact test. ISEL indices were significantly (P<0.0001) lower in PCa (0.1±0.3) than in primary PIN (0.5±0.3), while the MIB-I indices were similar in both conditions (P=0.56). Statistically significant differences were also detected for both MIB-1 and ISEL indices when secondary PIN (MIB-1 1.9±0.7, ISEL 3.7±3.3) was compared with primary PIN (MIB-1 2.5±2.1, ISEL 0.5±0.3) and PCa (P<0.0001). In terms of cellularity, primary PIN (26.3±7.1) revealed scores significantly lower (P<0.0001) than those recorded in PCa (39.0±8.8) and secondary PIN (32.9±14.3). In conclusion, early prostatic tumor is mainly defined by down-regulated apoptosis rather than by increased proliferation. Secondary PIN displays unique kinetic features suggesting an evolved stage of primary PIN.es
dc.formatapplication/pdfes
dc.format.extent8 p.es
dc.language.isoenges
dc.publisherSpringeres
dc.relation.ispartofVirchows Archiv, 536 (5), 413-420.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectProstatic intraepithelial neoplasmes
dc.subjectPrecancerous lesiones
dc.subjectIntraductal extensiones
dc.subjectCell kineticses
dc.subjectDNA-ploidyes
dc.titleKinetic profiles of intraepithelial and invasive prostatic neoplasias: the key role of down-regulated apoptosis in tumor progressiones
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Citología e Histología Normal y Patológicaes
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s004280050468es
dc.identifier.doi10.1007/s004280050468es
dc.journaltitleVirchows Archives
dc.publication.volumen536es
dc.publication.issue5es
dc.publication.initialPage413es
dc.publication.endPage420es

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